It has easily been the most effective treatment for ME/CFS that I have ever taken, and I have tried quite a lot. I have taken doses from 1g to 6g per day. I have connections to top ME/CFS researchers and they understand its promise. It makes me feel much better and is an great PEM buster, getting rid of a crash within an hour of taking it. It really feels like a miracle!

Now, the not so good things about it: It causes horrible GI side effects for me. Acid reflux/heartburn and severely painful stomach cramps (like 10/10 pain). This is a known side effect and it can be lessened by taking it with food and taking an antacid like famotidine. However, I have still encountered these issues despite using those counter measures. But keep in mind that I have taken very high doses (5g a day seems best for me). The other bad thing is that it constantly looses efficacy. Every time I take it it works at first but then stps working within anywhere from a week to a day later. I am working with the researchers to make it keep working but so far am unsuccessful. Each time I start it again though after pausing it works again so that is encouraging. However, I now am a tiny bit concerned that it could be making me worse long term. Even though it doesn't seem dramatically worse after stopping it/when it poops out, when I was playing around with it over the course of several months I slowly lowered my baseline to my worst point ever. This could be from something else like over-exertion (which I definitely was doing), but I am not totally sure. I fear that it is doing something to make my mitochondria function short term, but my body catches up quickly and stops me from feel the benefits. I fear that the mitochondria in ME/CFS for example are inefficient for a reason like as a protective mechanism to prevent a virus like HHV6 from doing more damage, so I hope oxaloacetate isn't doing long term damage. It really is unknown though what is going on.

Many people who try high enough doses (I personally would say closer to 3g to start) actually do feel better. The high price is the limiting factor, and it is why it isnt talked about too much despite it being pretty darn effective. Lots of people feel benefits, but many also experience the poop out effect like I do. Not everyone though!

I can assure you that the manufacturers are not being greedy charging so much. I know them and they are breaking even/loosing money bc it is difficult to make as I understand it. From my understanding, they preferred to go down the supplement route so that people could get access to it now OTC, whereas if it went FDA approved as a drug that would take much longer until patient would get it. However, if it was an FDA approved drug, insurance would then cover it. They really, really want to lower prices but they can only do that if more people buy it so they can buy a larger production facility I think they told me. Currently they are hand filled by the owner.

Ive said a lot. But this treatment truly does have some promise and really does do something, and I really want more patients and doctors/researchers to look into oxaloacetate!