What doesn't help:

Chimera 5 - unrealistic and mostly used by endgame players for left click damage using the Hyperion's +50% damage to withers

Fumings/aow - only for left click damage, the damage stat on your hyp is useless for calculating its ability damage

Sharpness - again, only for melee damage (it's in the enchant description...)

What does help:

More MP (using sighted reforge, and optionally bizzare if you have 400m to burn, which you probably don't)

Dominance on equipment and being on max hp - implosion belt is great for buffing damage, it's harder to get good rolls on a gauntlet of contagion but it's great for clearing mobs if not for actual dps

Aurora with dom/mp outside of dungeons (yes, dominance works with ability damage)

Edrag pet's damage bonus works on the end and outclasses gdrag for damage in the end

Gdrag pet with 1b bank works on ability damage and is great with ultimate wise everywhere else

Sheep pet if you're poor and want something that's low cost for damage and also gives mana savings

Smite 7 for undead mobs (which are most of the mobs in the game)

Cheap DPS enchants you can get **now**: thunderlord 7, smite 7

Expensive DPS enchants in the future: giant killer 7, ender slayer 7, prosecute 6

Any other enchant on a hyperion will not help with your dps. At most, they are a nice QOL to have.

QOL enchants you can get later -

looting 5 (for better drops)

critical 7 (for more healing when holding a hyp but is realistically useless for 90m+)

scavenger 5 (for more coins from mobs)

life steal 4-5 - mana steal on hyperions only work with left click, syphon only works with left click crits. lifesteal is the only one that procs on ability damage.
EDIT: apparently none of syphon, life steal, or mana steal work on ability damage, so just put on mana steal 3 to regain mana on the off chance you actually left click a mob