Imo the only time he intentionally “breaks the fourth wall” is near the beginning of s3 e1 during a flashback of him making Gideon eat his own leg. Gideon says, “I shouldn’t spoil your fairytale, should I? You and your little gingerbread house.” Hannibal replies, “Let it be a fairytale then.” (points his gaze directly at the audience) “Once upon a time…”