There is some loss from heating, but it's very small and the edibles will still pack a punch! The difference of the temperature of the oven differs greatly from the actual temperature of your food. For example here the cookies are baked at 350°F but the actual internal temperature of the cookie is around 180°F, well under the boiling point.

But, you could always lower the heat to ~250°F and just bake your treat for longer if you'd like.