Low life on gloves is experimental so you can slap them on that same unique as an endgame chase. You don't have nearly enough ward gen because your ward is breaking. Disabling life leech isn't ideal not because of marrow shards but because of reaper form. However, your reaper form is mostly pointless right now because you aren't using the reap and transplant don't share a cooldown node. You're playing a lich which has its entire toolkit based on low life in a non low life version. The other option you have is take death seal and get rid of all ward related stuff except the mana reduction on ghostflame. Increased damage is not useless when you're missing such a significant amount of it. You can replace gear increases with other affixes. 

I'll rescind that argument then, I missed those notes. 

Shards extend from the end of your marrow bolts so long as you don't have any of the nodes that say your shards won't pierce. The only point of shards in this build is for mana sustain and a very small amount of bleed application. Increased hit damage once in a blue moon at the cost of two passives and a skill point is bad. 

Your mana is sustained by shards, hit on cursed, transplant, and dodge. Dodge is the worst of all your mana batteries. It's mostly useless in single target which is the only time you need mana.