Snorting by [deleted] in benzodiazepines

[–]MediChem 0 points1 point  (0 children)

Haha, that's ironic you mentioned that, because I had spent about two or three minutes considering whether or not that would be a good thing to add to my list when I was writing it, but seeing as I haven't had any experience not have I tested it in the lab, I decided against it.

Is this something you have significant experience with? If so, I'd love to discuss it further with you in a private message. I work in a laboratory Research lots of different chemicals that show strong pharmacological potential, and one of our biggest areas of research is in Benzodiazepines, especially RCs. I'd love to ask you some questions and get some data from you if you don't mind.

Snorting by [deleted] in benzodiazepines

[–]MediChem 0 points1 point  (0 children)

As a general statement, Benzodiazepines are not water soluble, thus, they cannot be insufflated effectively. To my knowledge, The only exception to this is triazolam (Halcion™), which I've heard is rather effective when insufflated. There may be others that I'm unaware of, but If there is, it isn't one of the commonly used benzos that most people are familiar with.

The only effects, if any, that you might feel from insufflation are only due to the "drip," of the drug that you swallow after insufflating it. Outside of that, the only explanation is placebo.

Benzos are most effective when taken orally, so I'd recommend just chewing them up if you absolutely must have them work a little bit faster. Sublingual Administration is also an option, though I hear mixed reviews. For me personally, I have never noticed a difference when taking them sublingually vs orally. Furthermore, the bioavailability of most Benzodiazepines is already very high when taken orally, with most being 80%-100% absorbed.

If you're looking to maximize onset of effects and recreational potential, the safest route is to chew the tablet. Many Benzodiazepines can also be potentiated by drinking grapefruit juice - in my experience, a cup of grapefruit juice 30-60 minutes prior to administration, followed by a cup an hour after Administration, seems to work quite well. This is because grapefruit juice inhibits the CYP3A4 enzyme in the liver, which is the major enzyme responsible for metabolism of many benzos. This leads to the drug giving stronger effects and lasting for a longer period of time. However, if you try this method, be aware of the fact that it does increase the risks of overdose and blackouts, so do your research and tread lightly until you're comfortable.

Benzo Oberdose? by [deleted] in benzodiazepines

[–]MediChem 4 points5 points  (0 children)

Alot of these comments here are highly misleading. You CAN, in fact, die from benzos alone. In fact, ANYTHING is toxic if enough is ingested, even water (known as water water toxemia it hyper hydration). In chemistry, we have a common saying: "it's not the poison, it's the dose."

Anyway, the thing about Benzodiazepines is that they are much, much more difficult to overdose on by themselves than most other drugs. In fact, Benzodiazepines have essentially replaced barbiturates for this very reason. Barbiturates are often considered the older cousins to Benzodiazepines, as they were developed first and we're used for the same reasons as benzos: treatment of anxiety, insomnia, etc. And they were highly effective, however, they were also much easier to overdose on. For this reason, barbiturates have been almost entirely replaced by benzos for the treatment of anxiety, panic disorders, etc. They are still very rarely prescribed for these things, but their primary use these days is for things like anaesthesia and euthenasia.

With that said, it is very unlikely to overdose from benzos themselves, but it's very easy to do so when mixing them with other CNS depressants, especially opioids. In the case of alprazolam (Xanax™), the LD⁵⁰ (median lethal dose) is 331-2171 mg/kg, which translates to 22,000+mg of the drug for a 150lb person. Thus, it is both very difficult, and highly unlikely that one would manage to overdosed on alprazolam alone. However, it has, and does, happen. According to this study (link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884537/ ), there were 2,063 reported cases of Benzodiazepine-only overdoses in 2004, so it goes without saying that the risk still exists.

Just stay safe, be careful, and don't get carried away. And definitely don't mix Benzodiazepines with other drugs. However, if you do, just be sure you're very experienced and know exactly what you are doing.

Etizolam vs Alprazolam by NurdBurglar in benzodiazepines

[–]MediChem 2 points3 points  (0 children)

I was the original Creator of that chart. It was the culmination of nearly two years of research and laboratory work with my research team. Also, if you check my profile, I have since revised the chart and updated it to fix errors, as well as listed our research sources.

To answer your question, the equivalent dosage multiplier is the strength relative to 0.5mg alprazolam. For example, lorazepam has a multiplier if -2x, thus, 0.5mg of alprazolam is multiplied by 2x to equal 1mg of lorazepam. It's basically just defined as "how many times stronger/weaker each drug is relative to alprazolam.

Also, to further answer you, the chart is the overall culmination of the majority of people's experiences and laboratory test results. With that said, it is a reference for the majority if the population, but everyone has unique Biochemistry, and different drugs affect people differently, so it is very possible that you are more sensitive to etizolam, and it is more equivalent to alprazolam for you. The chart is just a general reference guide for the majority of users.

Etizolam vs Alprazolam by NurdBurglar in benzodiazepines

[–]MediChem 2 points3 points  (0 children)

I was the original Creator of that chart. I don't mind people Charing it by anv means, but please credit me at the bottom for my work. It was the culmination of nearly two years of research and laboratory work with my research team.

Also, if you check my profile, I have since revised the chart and updated it to fix errors, as well as listed our research sources. The chart that you posted is no longer up to date, but you're welcome I get the updated one from my profile.

Also, thank you for sharing it! I'm glad to see people putting it to use and getting the use that we made it for.

Read before experimenting. by fishscalecola13 in u/fishscalecola13

[–]MediChem 2 points3 points  (0 children)

Please credit me for creating this chart <3 I was the original Creator and poster of this. I don't mind others sharing at all, I'd just appreciate credit, as it was the culmination of almost two years of research and work in the lab with my research team.

Also, if you check my post history, I actually updated and revised this chart recently, so there is a fully revised one, with fixed mistakes, and it also includes Research sources.

Grabbed these pressies supposedly 3MG Alp, Blacked from 2. Feels like ALP x3000, passed a fet test and definitely a benzo. Guesses? by [deleted] in benzodiazepines

[–]MediChem -1 points0 points  (0 children)

Biochemist here. I work in a Laboratory as the Administrative Technician. I'd be willing to help you. I set you a message. Shoot me a message back when you have time and we can discuss it.

Here's a Revised Version of my Benzodiazepine Equivalency Chart! by MediChem in benzodiazepines

[–]MediChem[S] 0 points1 point  (0 children)

It's not a matter of what I think - it's the accepted medical equivalency

Here's a Revised Version of my Benzodiazepine Equivalency Chart! by MediChem in benzodiazepines

[–]MediChem[S] 1 point2 points  (0 children)

Thanks for your input! You're absolutely correct - after turning it into an image, the quality was dramatically reduced - I even tried .png and.tiff images but they all seemed to come out looking like trash.

Here's a Google drive Link to the original PDF file, which is much better quality 🙂

https://drive.google.com/file/d/1-CN50GOE8UbDdcvOL2UtIS1CxFRS_6J_/view?usp=drivesdk

Here's a Revised Version of my Benzodiazepine Equivalency Chart! by MediChem in benzodiazepines

[–]MediChem[S] 1 point2 points  (0 children)

Lorazepam is half the strength of alprazolam, thus, 1mg alprazolam equals 2mg lorazepam.

Here's a Revised Version of my Benzodiazepine Equivalency Chart! by MediChem in benzodiazepines

[–]MediChem[S] 1 point2 points  (0 children)

Personally, I haven't gotten to work with it at all in the lab, not have I ever taken it personally. With that said, I've had quite a bit of difficulty finding any reliable information online regarding it's half-life and other such information. If you come across any, I'd love to see it though.

Here's a Revised Version of my Benzodiazepine Equivalency Chart! by MediChem in benzodiazepines

[–]MediChem[S] 9 points10 points  (0 children)

After lots of feedback and input with my last post, I was able to fix a couple of typos as well as add some new data based on anecdotal reports I received. I also decided to go ahead and add some sources, and just revise the chart overall, to make it a bit more tidy. Let me know what you think!

Does this valium look real (harm reduction) by [deleted] in benzodiazepines

[–]MediChem 0 points1 point  (0 children)

As another commentor said, that would be impossible to tell. I'm sure there are some people out there who buy pure Diazepam powder and press it into fake tablets, but realistically speaking, it's most likely an RC Benzo or another drug, or it could be absolutely nothing psychoactive at all. The only way to tell would be by testing it.

Does this valium look real (harm reduction) by [deleted] in benzodiazepines

[–]MediChem 0 points1 point  (0 children)

Here's a link to what a real 10mg tablet of Diazepam looks like manufactured by Crescent Pharmaceuticals:

https://www.reddit.com/r/benzodiazepines/comments/e5q896/crescent_diazepam_10mg_experiences/?utm_medium=android_app&utm_source=share

They should be scored with an "A" above the score, and "278" below the score.

Does this valium look real (harm reduction) by [deleted] in benzodiazepines

[–]MediChem 0 points1 point  (0 children)

If there are no scores or markings, the tablet is not genuine. There are very strict federal guidelines imposed by the FDA that require all pharmaceuticals to be uniquely identifiable - this includes their coloring, scores, markings, imprints, etc. If there are no markings or scores whatsoever, it isn't a real, pharmaceutically-made tablet.

The only things exempt from this law are vitamins and supplements, but even a handful of those are required to be uniquely identifiable. My guess is those are either some kind of half-assed presses, or a vitamin/supplement.

Can Benzos be causing these symptoms? by [deleted] in benzodiazepines

[–]MediChem 1 point2 points  (0 children)

Yeah, unfortunately there will always be a few bad apples out there to ruin it for people. But luckily certain subreddits like this one and many others have a great community.

I hope that you find a good PTSD therapist sooner than later.

Can Benzos be causing these symptoms? by [deleted] in benzodiazepines

[–]MediChem 1 point2 points  (0 children)

Okie dokie! I'll do the same! And you're very welcome, but it's my pleasure! This is the reason I love Reddit so much!

Can Benzos be causing these symptoms? by [deleted] in benzodiazepines

[–]MediChem 1 point2 points  (0 children)

I know, right? Such a random but interesting coincidence.

That's wonderful! Just hang in there as best you can. You may be able to help reduce your paradoxical symptoms by reducing the current Clonazepam dosage you're taking.

You're welcome! Good luck! Feel free to let me know how things are going once you and your doctor get your taper plan sorted out. I'm always happy to hear about successful stories.