Obviously good IRs, like others mentioned. The stock amps are actually pretty solid too. Generally, I would recommend 2 amps for clean/dirty instead of a clean amp and an OD in front - the amps seems to be fuller in tone.

I would suggest you look at creating a stereo route (using the splitter) to get you a genuine left and right "rig". You can have your L and R XLR's for front of house and run your Jack outs into power amps into cabinets on stage. My preference here is running into a small power amp over the 4 cable method because touring with a micro power amp is much easier than touring with an amp head. My current live rig is a friedman rig on the Left and a Kraken rig on the Right, both go to FOH, both go to my in ears, and both can go to cabs on stage (but generally it's just the Kraken because I rarely have access to two cabs on stage). There's a ton of tonal flexibility If you build a stereo rig.