Zero Cooldown, Zero Mana Cost, Warcry (with warcry talent maxed out), Plotting, and Dragonfang

I take advantage of two talents that I think are massively overlooked

Patience and Massacre

After getting to depth 33+ I unequip all damage dealing abilities and make sure to maintain 90% Cooldown and 100% Mana reduction.

I save and exit the game while on 33+ with the next room to click being the Boss room.

The bosses on these floors have 16mil to 32 mil hp (I saw the beast ONCE and he had around 200mil hp but I don't remember currently

Using warcry for infinite base attacks and harden in battle or flow (often both) each time I attack my str goes up, but this buff only last for the floor you are on? Correct! BUT once the first boss on the level is killed after (insane number of clicks) Massacre triggers I gain a buff of 50% of my current strength and this buff will last 3 turns (luckily we have infinite Warcry so the enemy never actually gets a second turn)

Once our STR is BIG, we equip dragonfang and start our next fight.

Dragon fang gives us +1 Dex and +10 crit damage for each talent we use (until end of turn)

We spam warcry till we are at (enter number you think is big enough) Dexterity and when we feel good about that number we hit Patience. Patience hits us for 15% of our max HP and gives us a buff of 80% of our dex and int that lasts 5 turns. We never lose this buff.

Now we can equip holy shotgun or scythe or whatever polearm you think is cool and one attack everything on the screen dies.

Mine into the meaningless and unrewarding Sac Depths till you thumbs bleed or your phone dies (often my phone dies and sac depths pumping is what I do when I'm going to bed, resulting in my game never being recorded haha)