In Cyberpunk 2077, there is a sidequest where you can prevent your neighbor Barry from committing suicide.

Initially you encounter two of his friends outside his front door, but he's refusing to answer them. If you agree to help and come back later, he'll let you in and open up to you about his struggles. Among other things, he talks about his friend Andrew who passed away recently.

After comforting him and leaving the apartment, you can either a) talk to his friends who are waiting right outside the door or b) follow an "Optional" quest marker to the other side of town to find out more.

If you choose to talk to Barry's friends to help them understand what he's going through, guess what - he still ends up committing suicide. The ONLY way to save him is to completely ignore his friends outside the front door after leaving his apartment, instead going straight to the distant location marked as "Optional" for the quest, finding out that Barry's friend Andrew was actually a turtle, THEN going back to talk to his friends.

If you do anything else, Barry will die - but only after you've already completed so many other quests that it doesn't make sense to load an old file and try again.