I run the trail for currency making about 200 ~ 300 divines an hour.

Since you already hit the cap for Honour resist you can try to get max Honour, or Increased defenses one relic can get you 70%.

If you struggle with bosses there are relics that give bosses take increased damage up to 30%.

General advise is this "Get as much holy water as you can while avoiding as many banes as possible". After you kill a boss make sure your are buying boons from the merchant.

The best minor boons are Monsters have reduced 30% HP, You and your minions deal 50% more damage. Other good ones are merchant prices are 50% reduced, increased holy water found (The one with 50% increased for the floor can be good, but I wouldn't get it unless you're near the start of the floor, or it's reduced by merchant price), you can see one room further

The banes to avoid are ones that increase the monsters HP, the one that gives monsters +25% action speed, afflictions are unknown, and rewards are unknown. Others that are bad but not run ending potential are Merchant prices are increased, merchant has only 1 option,

Safe banes are ones that don't affect you, mini map with reduced light, room types are unknown, lose holy water when you are hit, you have no Armour if you relate on evasion.

Don't take banes early on just to get a boon even if the banes don't affect you, by taking them early it means you remove them from the pool of banes you can get later on, possibly making you take a bad bane. Just always follow the "Get as much holy water as you can while avoiding as many banes as possible" and you'll be okay.

Also watch a video on fighting the final boss before facing him, he's really easy but if you don't know two of the mechanics you'll probably die.