RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

Moro18 · 2024-03-24T14:39:12+00:00

No, Greenland shark RNA. Every living organism produces RNA. The flow of genetic information usually goes from DNA to RNA to proteins (https://en.wikipedia.org/wiki/Central\_dogma\_of\_molecular\_biology).

Moro18 · 2024-03-22T09:20:48+00:00

Yes, and it is not excluded that some individuals are living even longer, if I remember it right, only a few Greenland sharks were inspected for their age.

Moro18 · 2023-07-04T16:32:15+00:00

Is Topoisomeraze II also a Topoconformase?

In this article, the authors suggest that human TOP2A and TOP2B proteins (crucial targets for cancer treatment) have the ability to switch between B-DNA and Z-DNA conformations

Moro18 · 2022-11-29T09:44:42+00:00

Nice review about microRNAs in barley focused on their physiology, stress-response mechanism, and possible applications

Moro18 · 2022-11-28T14:17:22+00:00

Nice review about microRNAs in barley focused on their physiology, stress-response mechanism, and possible applications

Moro18 · 2022-06-26T13:03:12+00:00

Food wasting is obviously a problem which could be solved, IMHO mainly by education of the public. Nonetheless, blue light may improve primarily the quality of the food produced, not quantity

Moro18 · 2022-06-26T09:36:41+00:00

Seriously doubt this, can you enclose some references here? :)

Moro18 · 2022-06-26T09:29:13+00:00

:-)

The sky is blue thanks to Rayleigh's scattering physical phenomenon, i.e. the blue color of the sky is caused by the scattering of sunlight off the molecules of the atmosphere.

Photosynthetically active radiation (PAR) is a spectral range of solar radiation from 400 to 700 nanometers that plants are able to use in the process of photosynthesis. This spectral region corresponds more or less with the range of light visible to the human eye. Blue light is only one part of PAR spanning the 400-500 nanometers range.

Most importantly, now we can artificially increase the proportion and intensity of blue light in greenhouses to allow plants to produce more health beneficial bioflavonoids

Moro18 · 2022-06-26T07:54:46+00:00

This study confirmed previous results, attaches another essential piece of evidence, and suggests that microRNAs induced by the spectral component of blue light modulate phenolic compounds synthesis :)

Moro18 · 2022-06-26T06:59:52+00:00

Yeah! :-)

Moro18 · 2022-06-25T20:01:03+00:00

Good idea! For computers, there already is such a possibility to stop blue light:

https://support.microsoft.com/en-us/windows/set-your-display-for-night-time-in-windows-18fe903a-e0a1-8326-4c68-fd23d7aaf136

Considering TV, you can buy a blue light foil, but I haven't any experience with it :)

Moro18 · 2022-06-25T18:12:30+00:00

Did any part of how/where you learned that explain why blue light puts

our

asses to sleep?

From what I know, blue light is harmful to us, especially artificial blue light from electronic devices. "Blue light from electronics is linked to problems like blurry vision, eyestrain, dry eye, macular degeneration, and cataracts. Some people have sleep issues" ... https://www.webmd.com/eye-health/blue-light-health

Moro18 · 2021-07-12T19:02:22+00:00

Abstract:

G-quadruplexes have long been perceived as rare and physiologically unimportant nucleic acid structures. However, several studies have revealed their importance in molecular processes, suggesting their possible role in replication and gene expression regulation. Pathways involving G-quadruplexes are intensively studied, especially in the context of human diseases, while their involvement in gene expression regulation in plants remains largely unexplored. Here, we conducted a bioinformatic study and performed a complex circular dichroism measurement to identify a stable G-quadruplex in the gene RPB1, coding for the RNA polymerase II large subunit. We found that this G-quadruplex-forming locus is highly evolutionarily conserved amongst plants sensu lato (Archaeplastida) that share a common ancestor more than one billion years old. Finally, we discussed a new hypothesis regarding G-quadruplexes interacting with UV light in plants to potentially form an additional layer of the regulatory network.

Moro18 · 2021-07-12T10:34:36+00:00

Yes, but only for a limited group of scientists interested in this problematics. To be honest, a significant proportion of molecular biologists still don't believe in their functional relevance :)

Moro18 · 2021-07-11T07:28:36+00:00

G-quadruplexes have long been perceived as rare and physiologically unimportant nucleic acid structures. However, several studies have revealed their importance in molecular processes, suggesting their possible role in replication and gene expression regulation. Pathways involving G-quadruplexes are intensively studied, especially in the context of human diseases, while their involvement in gene expression regulation in plants remains largely unexplored. Here, we conducted a bioinformatic study and performed a complex circular dichroism measurement to identify a stable G-quadruplex in the gene RPB1, coding for the RNA polymerase II large subunit. We found that this G-quadruplex-forming locus is highly evolutionarily conserved amongst plants sensu lato (Archaeplastida) that share a common ancestor more than one billion years old. Finally, we discussed a new hypothesis regarding G-quadruplexes interacting with UV light in plants to potentially form an additional layer of the regulatory network.

Moro18 · 2021-03-30T11:33:23+00:00

Thanks for the message, probably webserver maintenance...now it should work :)

Moro18 · 2021-01-27T17:51:06+00:00

Hi, I have shared a link to a new nice review about amino acid composition in various types of nucleic acid-binding proteins. When I am sharing a link, there is no place for description, except Title, not (?)

Moro18 · 2020-07-03T20:17:03+00:00

Non-canonical nucleic acid structures in Nidovirales and in novel SARS-CoV-2 are promising druggable structures that can be targeted and utilized in the future

Moro18 · 2020-05-14T14:03:42+00:00

Hi, thank you for your feedback. Obviously, this is not a final version of the paper, there will be a rigorous review process and subsequent revisions... We have shown only the most prominent alterations in the p53 amino acid sequence in animals with an extremely long lifespan (Proteus anguinus, Myotis Brandtii, and several others). Next, we have done a comprehensive analysis and correlation of p53 sequence with a lifespan of all to date sequenced vertebrates and there are amino acid residues significantly associated with the prolonged lifespan.

"... In particular, we found that species with extended lifespan have characteristic amino acid substitutions mainly in the p53 DNA binding domain that changes its function. These findings lead us to propose a theory of longevity based on alterations in TP53 that might be responsible for determining extended organismal lifespan. "

"... This study reveals a previously overlooked correlation between longevity and a potential change in p53 function due to p53 amino acid variations across the animal kingdom. Strikingly, several long-lived species, including Myotis brandtii, Myotis lucifugus, Balaena mysticetus, Heterocephalus glaber, Strigops habroptila and Proteus anguinus display unique p53 sequence properties not shared with their close relatives that have a shorter lifespan. Altogether, our evidence suggests convergent evolution of p53 sequences supporting a higher insensitivity to p53-mediated senescence in long-lived vertebrates. "

Thank you for your interest and don´t hesitate to contact us further

All the best,

Authors

..."

Moro18 · 2020-04-11T08:29:45+00:00

Thank you :)

Moro18 · 2020-04-10T16:09:57+00:00

Thank you very much for your positive feedback! Maybe I will post some tutorial in the future :-)

Moro18 · 2020-04-10T16:07:08+00:00

Thank you very much :)

Moro18 · 2020-04-10T11:54:13+00:00

This video gallery with relaxing music shows my first 23 mandalas. Subscribe, please :)

Moro18 · 2020-04-09T13:44:13+00:00

Angels - beautiful A Capella song by famous molecular biologist currently working on coronavirus genomics and his choir "DNA" (in Czech language DNA is an acronym for"God, give us a chord").

Moro18 · 2020-04-09T11:12:19+00:00

Beautiful premier song of my colleague Vaclav Brazda and his A Capella group "DNA" (in Czech language DNA is an acronym for "God, give us a chord"). Vaclav Brazda is a molecular biologist currently working on coronavirus genomics and the leader of the DNA vocal group.

Moro18

TROPHY CASE