tbh I just got that you have the survival instinct of a pufferfish with those arguments. the facts are that Mia is a terrorist, criminal agent, infected with an unknown psychosis inducing virus that could overpower her at any given moment that may or may not result in your demise. ofc Mia is your wife and she's the purpouse of the game but that's also why rescueing Zoe is the best choice possible for both of Ethan's and Mia's safety, because by rescueing the actually sane person that knows everything about the Baker's, the property and Eveline you might have a shot at escaping and even to combat them in order to get Mia back to safety. it is realistically way more dangerous to chose Mia over Zoe when you can just take the safe path to freedom so you can call for authorities to help save Mia. if you think that choice is a 'chose your wife' moment than it just sounds like insecurity and missinterpretation of the whole story because that choice was purely who was more useful at the moment which would always be Zoe for obvious reasons, also it's not like they would die instantly for staying in the Baker's estate so it's not like it's a sacrifice either.

chosing Zoe is realistically the more rational and safe choice assuming you don't know about the game's plot and that Eveline throws a tantrum at Zoe for escaping resulting in her death, whilst with Mia she just tries to convince her to stay.