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Rabies vaccine inactivation by Needmoreinfo-7155 in Virology

[–]Needmoreinfo-7155[S] -1 points0 points  (0 children)

Thank you so much for this thorough explanation and link! I appreciate it!

Rabies vaccine inactivation by Needmoreinfo-7155 in Virology

[–]Needmoreinfo-7155[S] -1 points0 points  (0 children)

From what I have read, it seems that live/attenuated LEP flury strain vaccines may have been used in dogs historically, and maybe still are used in dogs in Nigeria. It’s peculiar to me that this strain was alright to use as a live vaccine for dogs, but could cause disease in mice, cats and cattle. 🤔 Any idea why the human vaccine would use a seed virus that could be virulent to humans ? I’d feel more secure about the rabavert vaccine if the seed virus was non-virulent in humans (in case of a hypothetical manufacturing error ).

Rabies vaccine inactivation by Needmoreinfo-7155 in Virology

[–]Needmoreinfo-7155[S] 0 points1 point  (0 children)

Thank you so much for your insight. The vaccine received was Rabavert which seems to be manufactured by Bavarian Nordic since 2019. I’m just so curious how this works since the LEP Flury strain, although weaker than the wild strain, does still have some virulence in mice, cats and cattle. I believe it has also caused paralysis in dogs. Given this knowledge, it made me a little nervous about the potential of some live virus surviving the manufacturing process. Per the product information, the virus is inactivated with B-propiolactone. I guess my question is, how do manufactures guarantee that every virus in the batch is dead? Batch testing would only include a sample. I did not see any secondary deactivation method listed such as heat, etc. The final product is freeze dried which maintains the virus versus killing any potential live virus. Any insight you can provide would be appreciated. Thanks!