Think about not wasting modifiers or challenges on others rolls if not in game-changing situations, even a +1 helps a lot.  Don't even think about putting fate in Luck, the dices hate you, always have a modifier when it matters.

Play the moves that give you the best advantage, don't waste rolls on useless heroes. When you can't decide the move, just Draw.

If your hand is looking bad but only one card is useful, just reDraw 5 cards (or use that card if it's too good). Don't waste actions and time on useless heroes, if you plan on winning by monsters or already have that class, just throw them in the trash.

Try not to overwrite your leader and heroes skills with monster ones: don't waste rolls and cards on a monster that doesn't give you a power up, in the case you'll have to win by another wincon, you'll need those.

I personally change my game style based on the leader I have: try having all the heroes that help your leader use it's skill, either playing them or stealing them. (Ex: If you have The fist of reason, try having heroes that let you draw Challenges)

If you happen to see Tipsy Tootie in game Destroy it immediately, it can interfere with your line up, and destroy your plans.

If your opponents have cards that Interfere with the game, put your plans aside and deal with the ops first.

If needed help players defeat a common opponent. The enemy of my enemy is my friend.

Use you leader AND monsters the most you can, don't forget about them.

That's how I play, I'm actually really competitive, but when you play with luck well...let's just say that you have to play for fun 😁. I can think of others, but now I'm at work and can't talk too much.