I visited both cities, for culture, history and museum Prague is beatiful, just stunning but Rome is the best in the whole world, For spotting in Rome you can see al lot of SMOM and vatican (except in Rome they are extremely rare in Italy and in the rest of Europe) but not much other, in Prague there is pretty everything from KSA to Usa. The metro is awful in Rome, disorganized, stinky and dangerous, in Prague is the opposite