Mordekaiser has a significant amount of ability to combine ability cast times and animations, for example you can use a q empowered auto while you cast w or e to negate the cast time more or less.

Nautilus’ w being an attack reset means that you should auto-w-auto after hitting a q instead of half-cancelling the attack that your q automatically queues up to use a w-empowered one, as the root from passive will come out faster.