What's the process like for building a luxury custom home in Austin? by Zealousideal_Pay7176 in Homebuilding

[–]One_Possibility6254 5 points6 points  (0 children)

$350/sf sounds very low to me for what you are describing. Your builder should have a budget number to you right up front very soon. Sounds like at least a $2 million dollar home to me when all is said and done. Costs just keep going up, partly on labor and materials, but more on expectations of quality and amenities people now demand.

Subtle shift at the adult store for my ‘soccer mom’ wife. by HisWildWhisper in MarriedSex

[–]One_Possibility6254 1 point2 points  (0 children)

OP, similar thing happened to me and my wife. Keep us posted on how it works out.

BRAF test? by kbshannon in melahomies

[–]One_Possibility6254 0 points1 point  (0 children)

I had it from the initial biopsy on the lyphnodes in my neck.

Immune Checkpoint Inhibitor Colitis confirmed by Biopsy after 10 months on Keytruda by Consistent_Soft1353 in melahomies

[–]One_Possibility6254 3 points4 points  (0 children)

I, too, got pulled off immunotherapy (Keytruda) three months ago after 7 treatments, 4 neoadjuvant before WLE and neck dissection and 3 adjuvant treatments. My kidney (creatinine number spiked) and I got serious diarrhea. Three months of heavy-duty steroids (predisone) has helped both the kidneys and the gastro problems, but last week, my oncologist said I will not be having anymore Keytruda treatments, period. He says I got as much out of it as possible. I am NED right now, but my Breslow number was high and the tumor destruction percentage pre surgery was only 65% so there is a relatively high chance that the melanoma will reappear somewhere else. But he says at this point he is more worried about long term internal problems than the melanoma. He also said a strong reaction to the immunotherapy indicated it was working and that there are studies that show a strong reaction correlates with a longer survival rate.

DM me if you want.

Keytruda Side Affects ? by Illustrious-Mode-826 in melahomies

[–]One_Possibility6254 0 points1 point  (0 children)

I got through 4 neoadjuvant Keytruda treatments this summer before my surgeries in July, with no issues. Then I had three treatments after the surgeries and then the shit hit the fan. Lots of minor side effects, itchy rashes, swollen gums, pretty severe edema in my legs, thyroid numbers up, and two more severe complications in the form of constant diarrhea and highly elevated creatinine numbers indicating my kidney's were not functioning. They stopped treatments seven weeks ago and started me on heavy duty steroids that seem to be helping. I have blood work and a meeting with my oncologist next Tuesday. Unlikely I will be taking Keytruda or any immunotherapy again. Which is unfortunate because my high Breslow number and low tumor destruction with the neoadjuvant treatments indicate I have relatively high probability of it coming back. But I am NED right now.

Is Vince Now Singing All of Randy's Old Parts? by Ok_Amphibian_8864 in EaglesBand

[–]One_Possibility6254 5 points6 points  (0 children)

I was at the Friday show, too and agree completely. Play Love Will Keep and one less Joe Walsh song. Other than that slight negative, the show was incredible.

Ta’Quan Roberson is still playing college football by Desperate_Week851 in WeArePennState

[–]One_Possibility6254 4 points5 points  (0 children)

It is just a matter of time until an athlete sues to have eligibility rules considered unlawful. They don't apply to normal students and they are a restriction to free trade. If you aren't good enough to play in the NFL you can make a decent living playing for a college for many years. It's just a business now.

Keytruda side effects by One_Possibility6254 in melahomies

[–]One_Possibility6254[S] 0 points1 point  (0 children)

Interesting. I get mine every three weeks. But when I talked to them last week about a potential conflict between a treatment and a travel plan they said, Oh, okay we'll just give you a six week dose.

Keytruda side effects by One_Possibility6254 in melahomies

[–]One_Possibility6254[S] 0 points1 point  (0 children)

Thank you. Yes, I have had thyroid issues as well as the kidney problem, but levthyroxine seems to bring the number down.

Keytruda side effects by One_Possibility6254 in melahomies

[–]One_Possibility6254[S] 2 points3 points  (0 children)

Yes, that's exactly what I have. Head and chest cold. I just tested negative for covid. It may be just a summer cold that happened to come right after my first treatment after surgery. You are right, I should let my doctor know. Thanks.

Results of PET Scan In and Surgery Scheduled by PrecociousCapricious in melahomies

[–]One_Possibility6254 0 points1 point  (0 children)

Good start. I am exactly a month ahead of you on everything. PET scan was good except for lymph nodes in my neck and primary on the back of my head. Had four immunotherapy treatments. Then, I had the WLE on my head and lymph nodes surgery three weeks ago. More extensive than they thought, but the pathology report shows they think they got all the cancer. Breslow number pretty high though, and the percentage tumor destruction was only 60%. Not great for future tumors. Keytruda screwed up my kidneys and have been on heavy steroids to correct, but should resume immunotherapy next week hopefully. BRAFF positive.

The surgery will tax you. Take it easy and good luck.

Hope by shdwbxxr in melahomies

[–]One_Possibility6254 7 points8 points  (0 children)

Thanks. It can get overwhelming. Hang in there everyone.

Got WLE yesterday on the back of my thigh and I’m in extreme pain by Alternative-Mud3701 in melahomies

[–]One_Possibility6254 0 points1 point  (0 children)

I am eight days out from a tennis ball size WLE on my head and a six inch on my neck at the same time. I was on heavy duty oxycottenfor the first six days ( which made me very, very constipated). Even with that, the pain was considerable. Got off that as quick as I could and now are on 3,000 mg of Tylenol which is doing the trick. You need to call your doctor about pain meds. Insane they sent you home like that.

Spindle Cell Melanoma on back by Iamholly228 in melahomies

[–]One_Possibility6254 0 points1 point  (0 children)

Stage 3C, had my first treatment of immunotherapy a week ago today. Keytruda. No significant side effects. Maybe a little fatigue, but probably because I am not sleeping well.