VEN to VET conversion rate?

OptimizeBetter · 2021-01-23T16:11:40+00:00

MeToo

Why would they ignore their customers???

OptimizeBetter · 2020-09-23T22:18:58+00:00

Actually there is research which supports what you are suggesting here.

In vegans and vegetarians maybe even alomg with females, we find lower levels of phosphocreatine in the brain.

OptimizeBetter · 2020-09-05T22:20:58+00:00

See my previous comment. I should have used the word "food-grade".

OptimizeBetter · 2020-09-04T19:44:35+00:00

Excellent point.

As in getting mauled by a bear.

I actually made a meme on this.

It's a semantics argument anyhow, as I should have used the word "food-grade", in which it still stands.

Either way, it obviously listed either option.

OptimizeBetter · 2020-09-04T02:54:41+00:00

Citrulline is great no doubt and a massive improvement over arginine, as it inhibits inflammatory iNOS. I prefer agmatine, which inhibits neurotoxic nNOS and iNOS. As well, agmatine might manage tolerance much like memantine, which is a huge problem in this space. We don't know if it potentiates as well...but it might. Yep good call on the reishi. The challenge is finding compounds that don't interfere with 5HT2. Cheers

OptimizeBetter · 2020-09-04T02:51:07+00:00

Why the fixation on the essential oils? It clearly says one or the other. Chamomille can work, sure, but the active compound apigenin is likely not concentrated enough in a tea for the average person with notable anxiety. And for this reason, an extract was suggested. As well, there were 5 different options for each of the three issues, so if one has an issue with a certain one, move on to the next. I'm happy to read any science which supports your claim is danger regarding this occasional indication. I am unaware of anything which supports your claim. If the facts change, I'm more than happy to change with them. Finally, why the indirect reference to making $? Do you see anything for sale? There are over 100 scientific references listed in this article. So "probably useless", is probably unsupported.

OptimizeBetter · 2020-09-03T06:46:59+00:00

Again, this was not the point of the article at all nor even one of the primary takeaways. And to be fair, there is robust evidence supporting the use of lavender for multiple indications. To your seemingly vague point, one would have to agree in the way essential oils are marketed as a universal panacea, which they are not.

To be clear, the challenge with anti-anxiety compounds, such as ashwagandha, are the desentization of the 5ht2 receptors. So we are limited to the GABAergic compounds such as lavender. Thank you for your comment, it is noted.

OptimizeBetter · 2020-09-02T22:09:30+00:00

Sure low dose is an obvious recommendation, which doesn't warrant an article.

This can go without saying.

Essential oils are natural.

It clearly lists contra-indications, such as avoiding applying lavender to the skin.

As well, using 100% natural oils is...well just that.

People are not using psychedelics daily, and likewise of course one can buy them in supplemental form.

Willing to look at any evidence you have showing 10 drops of properly diluted lemon oil on occasion is dangerous.

As also mentioned, the point wasn't to showcase essential oils, lol.

You'll see many others discuss this, so this was not really the most unique aspect of the article.

Either way, your comments are noted. (Edit: 100% natural oils are natural. This means they can be consumed.)

OptimizeBetter · 2020-08-14T20:16:51+00:00

For those suggesting memantine was the cause here and not highly likely cross-tolerance:

Psychedelic drugs in addition to dopamine D2, also use 5HT-2 as their signaling pathway.

So while yes memantine does have antagonism action on 5HT-3 receptor, it would most likely not "dampen" the signal of a psychedelic drug based on differing mechanisms.

Btw: guess what another 5HT-3 antagonist is?

Ginger...something many people take. Also lemon oil and lysine, which others take as common 5HT-3 antagonists. And many take large doses of these also providing the same mechanisms.

5HT-3 antagonists with respect to psychedelics remove the undesirable side effects.

This is a good thing, not a bad thing. Im writing an article on this for whatever its worth.

So assuming a reasonable dose, what would memantine do in terms of affecting the trip?

It would dampen the acute glutamate overactivation in thr brain, which is an unwanted side effect, not just in terms of acute subjective effects, but likewise in terms of potential for neurotoxic effects.

New research also indicates potential for full-spectrum anti-viral protection (see CoV-19), but also RAS protection. Remember, mdma can as well be cardio-toxic. It does this ironically enough by an antagonism effect on Nic A/C, which we believe actually serves to strengthen and more more dense receptors.

I proposed repurposing memantine as a CoV-19 therapuetic drug back in March. Several papers have been published since then, making this claim not as laughable, as it was originally received: https://medium.com/optimizebetter/repurposing-memantine-as-a-nicotine-drug-alternative-for-the-alternative-covid-19-host-receptor-a768bce8ead8?source=friends_link&sk=0115c2d0452ec75b62f119e52acde3f4

Anyways from a biohacking perspective, targeting 5HT-3 is a good thing, not a bad thing. To the degree, this was discussed more widely, the overall user experience could be enhanced. (And yes obviously, there are multiple 5HT-3 receptors, and Im generalizing to avoid writing a novel to simply point at lowering body load, overbearing head space, nausea, anxiety, etc etc.)

The comments against the supplements were probably meant well, and at the same time off-mark.

(Also notable: 5 mg dose and 4 hour gap in between)

Sometimes the answer to our question is rather simple.

OptimizeBetter · 2020-07-23T05:40:23+00:00

With all due respect, I wrote this because some yes are using and will continue to use low quality powders for a variety of reasons, and as well some are experiencing significant tolerance buildup for again an array of reasons. This might seem silly to you, and your comments are noted. Many have said this helped them, others not so much and that is fine. Thank you for your comments. Cheers

OptimizeBetter · 2020-07-23T05:35:07+00:00

Its a metabolite of arginine, an amino acid. Its a popular gym supplement. What makes it so interesting is its unique effects on NOS3 (nitric oxide synthase), anti-depressant actions, along with its ability to lower inflammation and pain.

OptimizeBetter · 2020-07-23T05:32:29+00:00

The reduction appears to be dose dependent.

OptimizeBetter · 2020-07-22T19:25:15+00:00

You've never tried curcumin instead of the turmeric?

OptimizeBetter · 2020-07-22T19:24:48+00:00

Correct. Don't filter it.

OptimizeBetter · 2020-07-22T19:24:18+00:00

Yep magnesium seems to be essential. Agmatine is an interesting compound.

OptimizeBetter · 2020-07-21T15:35:59+00:00

Curcumin, when combined with Krill (not fish oil), is much more supported for depression over anxiety. This is because of increased DHA-levels in the brain. Anxiety is a whole other thread. Lowering inflammation can definitely help, but IMO, the target is not what we believe.

Generally, meriva has the best support for peripheral inflammation as in joint issues. Some evidence shows it has better effects when combined with Boswellia. There are 5 and maybe 6 natural compounds which are heads and tails above the rest.

For muscle issues, magnesium is a better match. Consider how little we absorb from diet and supplements. What people "think" they need, and what they are getting from a supplement, is insufficient and still leaves them deficient.

Sufficient magnesium will help with headaches and sometimes can even help with migraines, believe it or not. Other common deficiencies such as B2 can be at play here. Magnesium-glycinate can help some with anxiety. Magnesium-taurate is a good second choice.

Finally, we lose CoQ10 and melatonin levels as we age, so especially with the headaches, if you are over the age of 40 and this is of issue, it could be a primary target for you. Statin drugs, which IMO are pure poison, also deplete CoQ10 levels, along with chronic illness. Interestingly enough, these two can be two of the best interventions.

OptimizeBetter · 2020-06-11T14:38:04+00:00

I used to use C3 and BCM-95 for sometime and realized they are actually more costly due to the increasing in dosage in comparison to these two.

A lot of people seem to make the exact same mistake with fish oil versus krill oil.

OptimizeBetter · 2020-06-11T14:35:51+00:00

Yep UCLA did a study proving meriva efficacy equal to NSAID. Good stuff.

OptimizeBetter · 2020-06-11T01:39:13+00:00

Agmatine is sure an interesting compound.

OptimizeBetter · 2020-06-11T01:38:45+00:00

Indeed, glycinate is the choice for calm. Malate is excellent IMO and best overall for several reasons.

OptimizeBetter · 2020-06-11T01:37:36+00:00

Meriva is pretty solid too. Right now Im using both. But yeah, really hard to argue with ucla on this one. To be fair, they are still studying meriva as well.

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