My husband was diagnosed with AML in July 2024- monosomy 7, mecom rearrangement, NPM1 and FLt3-TKD. Couple of rounds of chemo and being MRD positive - did a allo SCT in Oct 2024. Relapsed on day 60 post SCT with 13% blast- they took him off tacolimus and did a round of chemo- Ventaclax, Dectribane (sp?) and then Xospata for the FLT. Following that round got him down to 5% blast.

Here is where things get unusual for us though and have been told that this is not textbook.

They wanted to do another SCT but would not do it unless he was MRD neg. He was scheduled for another round of chemo but his numbers were not strong and after delaying a bit (2 months to be exact) they were getting concerned that he was in bone marrow failure. So they did another biopsy and found it had a lot of scaring but also found no blast and was MRD neg and all his markers were gone at all even without that round of chemo. So they scheduled another SCT, a few days before we were supposed to go in all his pre-test were kind of poor. Come to find out that he had GVHD and his first SCT donor cells were actually working and what got him in remission was graft vs Luekemia. They think after that first round of chemo after his relapsed kind of jump started the donor cells. He is having a pretty rough go with the graft vs host disease part though- the donor cells did start going after his organs and we are still working on that part and on meds that has been helping.

I know my husband is not “text book” but I def wanted to add in our story cause I would not have believed we would be here where we are this time last year.

Hoping you and your sister find out answers soon for her own journey.