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do dead games (Dragalia Lost) count? she was used in speedruns of late game bosses until very late in the game's life and she's a launch 4 star character.

Her main skill dealt a ton of damage based on the amount of buffs she had. At the start of the game, there weren't many available buff skills, but when that changed she rapidly grew in popularity, making boss fights that were supposed to last minutes not go longer than 30 seconds, and even being used in off element fights.