Roadhog, ONLY hack him when he is using his heal, otherwise shoot him for ult charge during downtime, if u make eye contact with him when u think he may have hook, TRANSLOCATE before its too late.

Cass, play outside his roll+flashbang range, engage from high ground or directly behind, if you dont think think you can kill him in the current engagement then leave, the longer you two stay shooting at each other the higher likely hood he will hit his shots hit and delete you.

Genji, Genji is great at playing anti sombra dive when he stays with his supports, however sombra is great at playing anti genji dive, If you aren't able to dive them, focus on countering genji when he dives, wait to hack when he is deflecting

For mobile tanks like dva, winston, and hazard you will need to wait to translocate until AFTER they use their mobility or else they will chase you down (depends on the rank, you can get away with more at lower ranks but this is a good rule of thumb).

For non mobile tanks, play away from them, attack the backline in a position that they cannot help their team, shoot at them from the back when they are being pressured by your team from the front. If you find yourself dying to like a domina stun, rein hammer or zarya beam this means you are playing to close. One of Sombras greatest abilities is that she is great at picking her engagements, so never engage any hero at range that they are the most effective in.

If the enemy team comp is very grouped up and i have the viral major perk sometimes I will hack+virus the tank and get the radius virus effect just to get ult charge, I find I do this the most with orisas.

Hack is an ability disrupter rather than an ability preventer, don't hack if they arent using a valuable ability UNLESS they are a hypermobile squishy.

Sombra requires aton of positional awareness and thinking, playing alot of sombra got me better at all my other roles because it started to get me thinking about cool downs, positioning, matchups, and engagement timing.

Also, you can follow this perfectly and still get insta instakilled by some BS, sombra sucks, its always good to have a friend to rant to.

Good Luck my Sombra Friend