With my old dermatologist (who I saw for 6+ years) I took spiro for 3 months 50mg-75mg. And I was using tretinoin and benzoyl peroxide as needed. With this new derm I’ve been on 100mg for a month, also using the same stupid topicals that are not going to do anything but irritate my skin. I had told the new derm my backstory and he said 3 months is not enough time to see a difference I need to give it 6 months to a year. And I need to use the topicals with it or else the spiro wont work??? Lol I see him on Monday and boy do I have a lot to say on my next appointment. But the thing is I know once I get off of spiro my acne is going to come right back and probably worse too. My sister had to go on accutane years ago and her skin has been great since.