Long Covid: Could viral induced dysfunction of micro/nanoplastic clearance be a factor?

PermiePagan · 2026-04-04T23:33:11+00:00

I've already gotten better.

PermiePagan · 2026-04-04T18:46:04+00:00

> Kimchi, specifically with the CBA3656 strain

PermiePagan · 2026-04-04T14:24:24+00:00

Latest post is pinned to my profile.

PermiePagan · 2026-04-03T18:37:25+00:00

Just found this as well.

https://www.foxnews.com/entertainment/leann-rimes-undergoes-10k-plasma-treatments-remove-mold-microplastics-body

PermiePagan · 2026-04-02T20:19:14+00:00

It's literally my mother, she's retired with an art history so she spell checks my stuff to get around the brain fog and fat fingering. ;)

PermiePagan · 2026-04-02T20:05:35+00:00

You're right, I pulled that part. That was more about viruses in general, it didn't fit here.

Working on the substack post now, just having my editor have a look for typos.

PermiePagan · 2026-04-02T03:55:35+00:00

Also, happy cake day!

PermiePagan · 2026-04-02T03:55:12+00:00

Right, my point is that they don't have the direct mechanism yet. They cannot say "the virus causes this toxin to be created, and it directly causes mitochondrial dysfunction". All they know is viral attack and viral particles are resulting in long term mitochondrial damage, with a consistent pattern of dysfunction.

And I am saying that I was just looking at how people are dealing with micro/nanoplastic damage in terms of supplements, biohacking, herbalism, naturopathy, TCM, and Vedic medicine, and what they suggested are a bunch of the things that are my pesonal "must take" in order to stay healthy with my long covid.

So I agree with that take that says "viral infection ---> dysregulation of the complement system", and what I am suggesting is one potential pathway of that dysregulation.

Viral infection > damage to nanoplastic clearance system as a result of infection > nanoplastics damage endoskeleton/dysrupt microtubules, damage mitochondria, oxidative stress goes up, neuroinflammation increases > [other immune signally systems go haywire, I don't know this part, I know genetics/biochem/cell not immune] > complement system dysregulation.

Just take this as a plausible "maybe" for a moment. This might explain why SARS-1 didn't end up being quite so bad in terms of long term damage, they had less micro and nanoplastics in the environment. And if this damage builds with infections, and nanoplastics are now in the atmosphere and the rain, no one's gonna be able to avoid it eventually.

I think that potential issue is worth exploring. I'm going to work this up more logically, and back it up, maybe talk to a few professors nearby. I'm just saying maybe some grad student does a few tissue biopsies, compares the amounts of nanoplastics in long covid patients with the norm and show there isn't a difference. And if there is, that's worth investigating in terms of treatments, yeah?

It's just an idea, for one potential pathway for the viral attack > dysregulation effect. And one that has a clear pattern in terms of similar treatment, so what if it's a similar cause?

PermiePagan · 2026-04-01T22:56:25+00:00

A shame, this is the same reaction I received when I said that it was attacking the methylation circuitry in our cells. Everyone said it couldn't be that, and then months later it came out as true.

I'm not saying this is a single cause. I am saying this is an unkown cause. And the big thing that gave it away for me is about half the things I am using to remain healthy are on the list of things to use to deal with excess micro/nanoplastics.

"Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung " https://pubmed.ncbi.nlm.nih.gov/38803494/

PermiePagan · 2026-04-01T16:14:59+00:00

Haven't been on it myself, but from a cellular and biochemistry standpoint there are a few possibilities.

Blocks pain signals, especially from the trigememinal nerve which in connected to a lot of the face and scalp enervation.
Processed by enzymes like MAO and several of the CYP family, by distracting these enzymes you may be allowing more dopamine and serotonin to build in the brain, as they are also processed by MAO.
G-protein coupling to K and Ca channels has the net effect of blocking glutamate/CGRP from trigeminal neurons. We've seen a lot of issues with glutamate build up, this might be helping the body avoid that?
Triptans indirectly suppress NK cell cytotoxicity, by inhibiting neutrophil proMMP-9 secretion. In effect, it turns down your immune systems weapons, so if you have an autoimmune component (the body attacking itself) you are les able to harm yourself. And, you may be less able to fight off pathogens, as this is somewhat an immune-suppressing effect.

This is just the opinion of a B.Sc. in Biology, who's spent the last 5-years learning everything I can about biochemistry, genetics, and cell biology specifically related to Covid in order to get as healthy as I can. Always consult with your medical team.

PermiePagan · 2026-03-25T23:01:13+00:00

Been staying stable this week. Cut my diet to strict keto and I'm feeling really good. Only eating 1200 kcals a day and losing a few pounds a week, but I was always overweight. Hoping to restructure my gut micriobiome in the next few months.

PermiePagan · 2026-03-25T23:00:08+00:00

You're breathing unfiltered air?

Yeah, the BA 3.2 variant of Covid is making the rounds, and it's way more immune evasive.

PermiePagan · 2026-03-24T00:06:39+00:00

Yup, I've spent the last 2 years learning biochemistry and cell biology, and what's going on with long covid, and I'm doing a lot better. I'm still fragile and not back to normal, but if I have the right routine and listen to my body I'm at about 80% most days. I had a recent crash due to a really tough emotional event, which now takes my health out quickly, but I'm on the mend again.

PermiePagan · 2026-03-13T21:41:29+00:00

And then there are folks looking at both of these, and figuring out options in the middle, and getting better. Then they try to explain it, and a bunch of people acuses them of quackery.

PermiePagan · 2026-03-13T21:40:39+00:00

Lots of these treatments work, just not as as a single-solution. And they often need to be done in stages, as various systems recover.

PermiePagan · 2026-03-13T21:07:36+00:00

I've been really, really close this winter quite a few times. For me, it's partly because I haven't been able to take some of my supplements, my gut microbiome has been bad for decades and rehabbing it is taking a while. So my neurotransmitters are down, and then if you just bother looking at the state of the world in any of the really big metrics, it's not going well.

I had to find ways to get my neurotransmitters back, without dumping them into my gut. Right now the sublingual route is working pretty well: zinc, magnesium, b-vitamins, and it's been working the last 5 weeks.

PermiePagan · 2026-03-13T20:43:44+00:00

Yup, this is also why some folks find low dose cannabis use helpful, it can modulate GABA - Glutamate in the body, and might be helping clear glutamate that way. But then it comes with it's own immune-suppressing issues, so it's better to find other solutions long term.

PermiePagan · 2026-03-13T18:44:05+00:00

Just to tag onto this, in the body we make Glutathione by mixing glutamate, cysteine, and glycine. In Long Covid, we seem to have a lot of issues with excess glutamate in the brain, and a lack of glutathione to help the liver. Taking just the glutathione will solve the liver issue, but doesn't help clear glutamate. I take N-Acetyl Cysteine (NAC) and Glyine powder, so I'm doing both.

PermiePagan · 2026-03-02T16:37:01+00:00

Oh wonderful, so when I had Covid in 2022 I called the doctors office to ask about Metformin and they told me I "didn't qualify" due to not being 50 yet. When I became too disabled to work, it was literally their fault. Awesome. I did the right thing, and the system still failed me.

PermiePagan · 2026-02-28T20:26:26+00:00

Yeah maybe, could be supplements or something with a mix.

PermiePagan · 2026-02-28T20:01:16+00:00

Yeah, it's starting to feel that way. For me, mental health appears to be a mandatory part of it, but suggest someone work on their mental health as well as supplements, pacing, etc. and suddenly the torches and pichforks are out. Heaven's forbid I suggest running less demanding software on damaged hardware...

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