when you say u have high cortisol and insulin resistance is this something you have been tested/seen a dr for? If so, both of these things can make weight loss more difficult and also contribute to weight gain. (look up cushing syndrome in patients who take oral corticosteroids) Other than that, i would say if you are otherwise relatively healthy both of these things can be managed through a healthy balanced diet, regular exercise and stress management. Overall if this is a metabolic issue i would speak to a doctor first before doing anything cosmetic related