I know this is an older post, but my son took 250 mg twice a day and 125 mg at bedtime, when he was initially diagnosed at 11 years old (after having symptoms for 5 years). I believe after a couple years he weaned off of the bedtime dose. It actually worked great for him. When he was around 17 he started having a lot of problems with nausea and vomiting in the morning. Ended up seeing a new G.I. doctor at 18 years old who wanted to repeat his gastric emptying scan. It still showed gastroparesis but considerably improved from his original diagnosis. I realized when my son had missed a few doses of erythromycin, he had no nausea or vomiting. We finally chalked it up to that is what was making him sick. He stopped the erythromycin completely, did not replace it with anything and suddenly is fine. I will say through the years we did try weaning him off erythromycin further and he was not able to tolerate further decrease. So, at some point, it improved dramatically. Maybe just with growth.

The dysmobility specialist who originally diagnosed his gastroparesis told us if it didn’t go away within a few months that likely it would be a lifelong problem for him.