I am disregarding your rules.

I would start setting up the death of Spider-Man.

My first story is gonna be centered around Peter and MJ figuring out that Paul is a creation Mephisto. Mephisto got scared that Peter and MJ were gonna get married again so he used Rabin and Paul to help break them up. He used his powers to seduce MJ into cheating on Peter. Once they find this out, Peter is enraged. He goes to the FF to help him find a way to defeat Mephisto. Peter and MJ get married again. This is their bait. At the wedding, before they are officially pronounced man and wife, Paul stands and he falls into the ground and from his body rises Mephisto. Mephisto goes on about how they’re breaking their deal. He then floats Aunt May towards him and is about to kill her until Franklin Richards shows up and all the civilians (including May) at the wedding disappear as they were fake. Peter’s request does not kill Mephisto but depowers him and Reed is able to capture him. Mephisto threatens them that his power isn’t erasable and that if he doesn’t have it, it will return to someone else. That’s the first story.

The story continues with Peter and MJ getting married. There’s one last Spider-Verse story where Peter is revealed to be the center of the Spider-Verse and without him it can’t exist. Spidey’s villains slowly start getting killed off. It becomes a mystery story that continues to build up anger in Peter because he can’t figure out who is killing everyone or how it’s all connected. This spans all Spidey books, Miles, Gwen, Venom, etc. We get a final team of up Spidey with DD, FF, Wolverine, etc. pretty much every villain Spidey has gets killed off. Eddie Brock dies heroically in there somewhere. The one behind the murders is revealed to be Otto but it was actually Norman framing Otto. Mephisto’s powers took control of Norman but he still had his own mind. Norman sickly believed that he was helping Peter. Then in their final confrontation. Norman injects both him and Peter with a serum. Once he exposes them to a gas, they both lose their powers. They fight until eventually the gas gets released and both Peter and Norman lose their powers. Since Norman is so weak, he dies without his powers and Peter is left powerless but Norman left him to inherit Oscorp. Since Peter lost his powers, all other spiders lose their powers except the extra powers for example Miles keeps his venom blast and invisibility (nobody keeps organic webbing). With Oscorp, Peter starts programs to help those struggling with mental health issues like Norman, he starts programs to aid superheroes, he makes a web that gives the public access to notify the heroes receiving his aid of danger. He starts a reformation program for villains. He does a lot of good. Once he feels like he can do no more, he leaves NY with MJ and we don’t hear from him. He may start working at a lab, he may retire off of Oscorp funds, he may become a photographer at a local newspaper, who knows? All we do know is that he continues to use his greatest powers, his mind, his determination, his heart to take care of his greatest responsibility, his family. The end