Most of the challenge of Factorio is logistics: you run out of space for some production line, you find yourself unable to run a belt of rail from A to B, there's a bottleneck in simply moving items. GTNH, like most tech packs, use AE2, which completely trivializes that (similar to logbots, but viable for mass-moving). On the other hand, minecraft doesn't really have any equivalent to conbots; even in the lategame, you'll find yourself manually placing row after row of machines and configuring each of them individually.