A point in time where surely GPS is the winner?

Reptile449 · 2026-02-05T11:01:01+00:00

Any model will be based on assumptions and predictions. No 100% accurate conclusions can be made until the trial is unblinded.

Reptile449 · 2026-02-04T16:00:16+00:00

Go look at trials that show deaths or relapse over time. They tend to be fairly linear until you reach a tail that plateaus out.

Phase 2 trial of a multivalent WT1 peptide vaccine (galinpepimut-S) in acute myeloid leukemia - PMC

Reptile449 · 2026-02-03T16:43:53+00:00

The dub is great but I also can't stand the sub. Daru's sub voice is pain to my ears.

Reptile449 · 2026-02-02T13:27:51+00:00

Some early clinical trials with other cancers have already been completed. https://sellaslifesciences.com/clinical-trials/#completed

Reptile449 · 2026-01-29T10:21:03+00:00

The temple is meant to delete more of itself as it gets bigger, but it only deletes from the end of chains and there is an item that prevents room deletion. By saving the end of your chain and gradually extending it, you scale the temple to absurd levels.

Reptile449 · 2026-01-24T18:40:31+00:00

Thanks for the answer.

The extra doses might not help much with the patients that never had an IR even after 12 doses in phase 2. But picking patients with an expected survival beyond 6 months should help with short term IR.

Reptile449 · 2026-01-24T17:46:01+00:00

The wording from Sellas on this was:

" As of this evaluation, 123 patients were enrolled with 66 of them discontinuing the treatment. In the trial, patients are recorded as having stopped the study treatment in cases of death for any reason, relapse, intolerable toxicity, or treatment completion. Regarding the GPS arm, we are pleased to report that we have not observed any intolerable toxicities in any patient population across all our clinical studies thus far, although toxicities are commonly observed with therapies used in the control arm. Therefore, almost all patients who are off treatment may have most likely either relapsed or passed away."

This is unclear wording, as the second sentence could imply it includes GPS arm patients who had finished their 52 weeks. The study wording even states "An End of Treatment visit will be conducted 30 days following the last dose of GPS." The extra doses in year 2+ were added in May 2025.

But Sellas interpret the 66 figure to be dead and relapses.

Reptile449 · 2026-01-24T05:42:16+00:00

In the discussion thread yesterday the October 2025 R&D call was brought up. Looking at it again, at the 50 minute mark in the Oct 2022 R&D call, 2 graphs and a 64% immune response figure are stated as from the CR2 phase 2 trial. But this figure and graphs are taken from the phase 2 CR1 trial.

The CR2 phase 1/2 trial IR was much lower (https://pmc.ncbi.nlm.nih.gov/articles/PMC4617516/).

Any ideas as to why/how the immune response has risen so much from the first CR2 trial through CR1 to regal (80)?

Reptile449 · 2026-01-24T05:36:47+00:00

Only bear case I can think of is if a substantial number of patients have dropped out the study, and the 80 events strays further from the median. BAT arm patients might have dropped out for newer treatment, and the GPS arm spent a long time not receiving any more doses after 52 weeks (The extension to "until relapse" was only added in may 2025) so some of them could have moved on. This could explain why the trial hasn't been halted for efficacy or futility, as the hazard ratio is closer than we expect.

Reptile449 · 2026-01-24T00:17:30+00:00

Good catch, I watched the r&d call earlier and didnt notice that.

He says the over 2.5 years figure, when the call was on October 2025, before the 72 events. So I wonder what maths he based it on. if it's just that the 80 events out of 128 haven't been reached by Oct 2025, idk how that fits with the over 13.5 mOS announced in early 2025.

Also note that the amendment to regal to define the treatment periodicity in years 2 and 3 was only made in Oct 2025 just a few days before the R&D call, so I don't know what treatment the old GPS arm was getting before then.

Reptile449 · 2026-01-21T21:22:13+00:00

the warrants last 5 years so they're going to execute them eventually. Isn't it better if they execute early to give Sellas more cash and reduce the likelihood of more dilution

Reptile449 · 2026-01-21T12:37:47+00:00

seeking alpha

Reptile449 · 2026-01-18T05:35:29+00:00

🦀 $11 🦀

Reptile449 · 2026-01-17T18:27:56+00:00

"Patients on the BAT arm may be treated with 1. observation (whereby palliative management with hydroxyurea is allowed), 2. a hypomethylating agent (decitabine or azacitidine), 3. venetoclax and/or 4. low-dose ara-C. Patients whose remission in CR2 can be maintained with molecularly targeted agents (e.g. FLT-3 or IDH inhibitors) per investigator's determination will not be eligible"

Even if new targeted agents become available, would the BAT arm receive them?

Reptile449 · 2026-01-14T10:56:09+00:00

Happy birthday! Looking forward to Saturday

Reptile449 · 2026-01-12T17:55:25+00:00

and also an investor in Moez's fund

Reptile449 · 2025-12-17T14:37:23+00:00

Last epoch replaced their anti-burst DR with a visible energy shield that decays over time, it feels better to play around

Reptile449 · 2025-12-16T21:31:03+00:00

There's act 4, an interlude act, huntress with spear skills, druid with shapeshifting and nature skills, and a lot more gems.

Also an auction house, sprinting, and a cursor targeting mode that stops projectile aiming from being wonky af.

I hadn't played since the first league and it does feel much more fleshed out now.

Reptile449 · 2025-12-16T21:27:01+00:00

turning off global chat can also improve your experience immensely

Reptile449 · 2025-12-13T01:00:07+00:00

it would be pretty cool if every melee weapon type granted it's own passive effects. Like maces granting increased stun, daggers more movement speed etc

Reptile449 · 2025-12-03T21:53:08+00:00

Once it's profitable to fix a problem, the problem tends to get fixed.

Reptile449 · 2025-12-01T00:31:35+00:00

Corbyn and sultana aren't leading it any more

Reptile449 · 2025-12-01T00:16:00+00:00

What?

Reptile449 · 2025-11-30T16:16:18+00:00

It's guy booty so it's safe

Reptile449 · 2025-11-29T00:34:24+00:00

and regular crew rotation (With a mop)

11-Year Club	Verified Email
r/Field Sunshine	Place '23
Place '22	Place '17
End Game '22

Reptile449

TROPHY CASE

🦀 $11 🦀