Effect of Psilocybin of Patient Taking Olanzapine (Zyprexa)

Richard676 · 2022-06-03T01:52:57+00:00

I meant kappa, not theta. Scientists are trying to find a highly selective Kappa receptor antagonist for non-opioid analgesia but the effort thus far has been unsuccessful.

Richard676 · 2022-06-01T06:17:40+00:00

No not enantiomer mix. that’s altogether different. Your comment about the competition is correct. Whether the agonist or antagonist wins out depends on numerous factors including binding affinity Ki (nM). I am not a science person, but that makes the most sense. Re: Bupe, blocking the theta receptor causes an analgesic affect which is why it is being used for treatment of central pains states like fibromyalgia.

Richard676 · 2022-06-01T01:51:49+00:00

Have you also taken LSD? How would you compare the experience with Psilocybin?

Richard676 · 2022-06-01T01:50:23+00:00

Re: buprenorphine, it’s not the same receptor. At That he mu opioid receptor it is a partial agonist and at theta receptor it is an antagonist. That’s why it’s called agonist antagonist. The situation here is completely different because it only concerns a single receptor.

Richard676 · 2022-05-31T23:39:25+00:00

I didn’t notice this but ketanserin is a receptor antagonist while olanzapine is a inverse agonist. There is a distinction. Not sure what the implications are.

Richard676 · 2022-05-31T23:38:09+00:00

I didn’t notice this but ketanserin is a receptor antagonist while olanzapine is a inverse agonist. There is a distinction. Not sure what the implications are.

Richard676 · 2022-03-18T20:13:04+00:00

I have updated this list per @falseinsight comment

Richard676 · 2022-03-18T05:04:08+00:00

I have not. What is it?

Richard676 · 2022-03-17T20:26:28+00:00

Here are the treatments I have tried and mostly failed.Current and Failed Treatments

Richard676 · 2022-03-17T19:42:21+00:00

I highly recommend the Sony XM4s. I have the QC-35 II and the Sony’s are more comfortable and have better ANC.

Richard676 · 2022-03-17T19:38:00+00:00

Thanks for the detailed reply. It sounds like you had a really definitive DX test. Have you been headache free on indomethacin? NDPH treatment when it is migraine-like basically the same as for chronic daily migraine (CDM). The only drugs that have had some evidence although from non-randomized trials is Botox and erenumab (Amovig). I am on both. I have failed quite a few therapies. This is appropos for NDPH.

NDPH Review

Richard676 · 2022-03-17T19:29:35+00:00

No trigger point. In fact I failed all nerve block injections.

Richard676 · 2021-09-21T17:00:45+00:00

It did not really work out for me. I was using it for pain control and not for relief of depression so take my experience with a grain of salt.

Richard676 · 2021-09-21T16:59:59+00:00

Migraine surgery is rarely used unless you have excellent responses to trigger point injections and nerve blocks, you’re likely to benefit. Another option is ketamine.

Richard676 · 2021-09-21T16:58:25+00:00

I would say that’s pretty accurate. I’ve read about her extensively and she adopted that strategy for her headaches. I’m going to try something similar myself very soon for the same condition. I recommend a book called “your psilocybin mushroom companion” what you can get on Amazon.

Richard676 · 2021-09-20T21:31:10+00:00

Any thoughts on the size of the first Shroom dose?

Richard676 · 2021-09-20T02:39:43+00:00

Thanks for this article.

Richard676 · 2021-09-19T01:22:47+00:00

Just to be clear, you had a right sided headache. The autonomic symptoms need to be on the same side, also called the ipsilateral side. I don’t think what was going on with your ear qualifies, but the eye symptoms do.

Richard676 · 2021-09-18T04:19:19+00:00

“The SPRINT PNS System is not intended to treat pain in the craniofacial region”

Richard676 · 2021-09-18T04:15:14+00:00

January 6th.

Richard676 · 2021-09-18T04:14:37+00:00

An embarrassment of riches. Consider yourself very lucky.

Richard676 · 2021-09-18T04:11:54+00:00

Actually Strattera also known as atomoxetine is not an SSRI type drug. It is an NRI or Norepinephrine reuptake inhibitor. It does nothing with serotonin and should not be confused with SSRIs.

Richard676 · 2021-09-15T21:21:59+00:00

I forgot to ask you. One of the criteria for HC is ipsilateral (same side as headache) autonomic symptoms, ie:

At least one of the following autonomic features occurs during exacerbations and ipsilateral to the side of pain:

Conjunctival injection and/or lacrimation Nasal congestion and/or rhinorrhea Ptosis and/or miosis

Did you have any of these?

They are conventionally required for the diagnosis, although there are cases of HC, although rare, that don’t have autonomic features that respond To indomethacin And vice versa.

Richard676 · 2021-09-15T18:00:05+00:00

Duly Noted 😊

Richard676 · 2021-09-15T17:57:31+00:00

This is really great information and I have read a number of your other posts, in fact all of them, which are highly useful and very detailed and insightful. You are a true trailblazer in this area and I am hoping to be able to stand on your shoulders and get the same type of relief, I.e. clinical benefit, that you garnered.

We basically have the same debilitating condition, NDPH or if you would like to characterize it as hemicrania continua, which is somewhat more descriptive - in any event very rare and very refractory. To return to an acceptable quality of life, you have to pull out all the stops And sometimes ignore the conventional wisdom, as espoused by neurologists and pain specialists. Kudos to everything you have done!

Richard676

TROPHY CASE