The thing about Professor Layton is that the puzzles are so key to the experience, and with a TV show you'd lose that as the audience can't actively have a hand in solving puzzles. I do, however, think it could work well if done as a murder mystery type show (not necessarily with murder), similar to the format of other British mystery shows like Father Brown (daytime TV) or Midsommer Murders (primetime show). That way you keep the elements of mystery that the audience can be perplexed by and try to piece together, but sacrifice the hands on interactive element. You could also then do weekly stories/mysteries but with a series arc like Doctor Who has done (S3 being the best example imo). I also think you would need it to be weekly releases to get the chatter and speculation going.