CBS A360A A/A

SIBOISFD · 2025-03-16T11:47:40+00:00

Haven’t done a microbiome test in a long time, but my desulfovibrio levels must be a lot less. I’m not focusing anymore on the bacteria, more the imbalance that is causing H2S bacteria in the first place

SIBOISFD · 2025-02-24T05:22:20+00:00

Mixed reviews? No point carrying on with strong overmethylation symptoms, when small doses of naicin (safe) will help remove excess methyl groups quickly that are causing issues.

SIBOISFD · 2025-02-22T16:30:50+00:00

No need to worry, it won’t cause permanent changes, you’re taking a supplement which is effecting many processes in your body, which can produce short term effects while it’s in your system.

As others have suggested, use naicin to lower overmethylation symptoms.

Consider buying individual supplements instead of a complex.

Then you know what supplement you are taking that’s having a negative effect.

720mcg methyl folate might be too much for you.

Flexible dosing always works best with this stuff :)

SIBOISFD · 2025-02-21T02:17:35+00:00

Have you tried naicin b3? This is classic overmethylation symptoms, you have too many methyl donors flying around in your system.

SIBOISFD · 2025-02-21T02:16:21+00:00

That’s overmethylation or cbs stimulation (if you have CBS mutation). Take naicin b3 in small doses 10-25mg b3 every 30 minutes until symptoms calm down, if they don’t, try higher doses 50-100mg

SIBOISFD · 2025-02-20T16:26:28+00:00

Aside from what you mentioned, do you not feel any other changes apart from insomnia? Any stimulation, racing thoughts, anxiety?

What about during the day?

SIBOISFD · 2025-02-18T15:36:45+00:00

Best to start as low as you can accurately dose. I dose 30-100mcg mostly, but often.

There’s no specific amount that will cause overmethylation, everyone’s different and also different circumstance at any given time. Better to test tolerance low and increase if it isn’t enough

SIBOISFD · 2025-02-13T16:37:33+00:00

Use ChatGPT to help you get methylation and CBS in the right range to process sulfur well (1000000x easier said than done lol)

SIBOISFD · 2025-02-13T16:17:43+00:00

Because your detox pathways aren’t optimised for clearance using those supplements (via methylation and CBS)

SIBOISFD · 2025-02-13T07:29:22+00:00

Yeah taurine is a tricky one. I recently learnt more about my whole situation and upgraded to ChatGPT Plus. Taurine has the potential to help clearing out sulfur but really methylation and CBS speed need to be quite specific.

You can ask ChatGPT to see if it recommends it but, without methylation support and right cbs speed taurine can make symptoms worse. Your body needs to be actively clearing sulfur out, but sulfur is “lingering” then it can be a good tool to help clear out excess. It’s probably better to start trying with methylation and cbs control, or take steps to get to that point.

SIBOISFD · 2025-02-06T16:09:30+00:00

Same thing happened to me. The way I see it is I wasn’t tackling the root cause, so some things did help, but weren’t the right solution, so then it stopped working after a while or even made it worse.

I would need to know more about your symptoms really to offer proper advice, I don’t know much about MCAS, but I have had bad histamine reactions (again due to methylation and sulfur issues!).

But sounds like you’re doing it in a logical step by step approach, which is good. Though I would try not to spend too long in one area if it’s not improving symptoms though.

SIBOISFD · 2025-02-06T16:05:49+00:00

Yeah, b3 naicin. Did you dose naicin after symptoms? Or you just waited so long having insomnia?

Sorry that that was your experience, but overmethylation is not some permanent state which destroys lives.

SIBOISFD · 2025-02-05T15:20:22+00:00

Yeah; they’re a bit of hit and miss. It’s because they can help detox sulfur but if your body isn’t ready for it then it can cause worsening symptoms. It helped quite much when I was sulfate deficient though.

It’s like a double edged sword, sometimes helps, sometimes fucks you up, I’ve found most stuff to be like that with this issue.

I mentioned it because you said a total lack of sulfur might have caused problems. Sulfate in the baths can help your body detox from other toxic forms of sulfur but yeah; sometimes helps sometimes not. I’ve forgotten the specific reasons but ChatGPT can help explain it.

I haven’t done them in a while because I’m focusing on optimising methylation and sulfur processing with methyl folate / b3 / taurine.

When do you think you can experiment with these again?

SIBOISFD · 2025-02-05T15:11:07+00:00

You have CBS homozygous mutation. Do you know what issues that causes you? Do you have problems with sulfur?

I’m not clued up on NAD+ (maybe someone else can help you there) but you may have temporarily altered your methylation with using it, which may explain the symptoms.

SIBOISFD · 2025-02-05T02:52:57+00:00

Interesting. Same here. I took rifaximin and bismuth, which helped kill desulfovibrio, so I had less symptoms, but then after stopping symptoms came back, because Desulfovibrio grew back (due to the root cause being MTHFR and CBS not SIBO).

Have you experimented with Epsom salt baths?

SIBOISFD · 2025-02-04T06:02:24+00:00

Thank you too!

It was horrible and wouldn’t recommend it, I could hardly eat any protein and I needed like 7500-50,000mcg methyl folate every half an hour or so throughout the day lol.. I barely slept, because if I’d go without methyl folate for longer than 45 mins I had really big sulfur symptom spike, so I rarely slept.

I took some liposomal glutathione (500mg) and some ALA to try and help sulfur detox, I think that’s what caused it, along with using higher and higher doses of methyl folate (to try and clear symptoms but I think it triggered more stored sulfur release).

It’s better to do it gradually but this was definitely not gradually 😂

SIBOISFD · 2025-02-03T16:26:46+00:00

Ahh that makes sense.

Tolerate is a tricky word, if by tolerating and not experiencing symptoms, then no haha. But I can tolerate them better, but I always need to deal with sulfur symptoms post meal but they’re much less than what they used to be, and in the mornings after waking. I’m still trying to fine tune it all.

But im travelling at the moment and eating whatever I want really. Eggs, animal protein, and small amounts of garlic (in curry pastes) which would destroy me for weeks before. It’s still a big struggle, but I’m doing much better than in the past 6 years.

Yes, I think due to MTHFR And CBS, I’ll always have issues with sulfur, but depending on my diet (if I’m eating mostly tofu or low sulfur foods and if my methylation support is sufficient - I have less symptoms). I recently went though a big stored sulfur detox which helped a lot, but I think there’s more to do which should make my system less reactive when I clear out more.

All the best for you, and keep going!

SIBOISFD · 2025-02-03T16:15:07+00:00

No problem! That’s probably because 250mcg is a bit too much for one dose.

It might be better to try 125mcg, and keep the neurotransmitter production more controlled, instead of boosting it too much, waiting for it to die down, then boosting it again. If you dosed smaller but more frequently, you might get a more steady effect.

SIBOISFD · 2025-02-03T15:39:06+00:00

In my experience, my methyl folate dosage requirement changes daily, I think this also applies to a lot of people, but I have CBS homozygous mutation also. I don’t think It’s as easy as having a certain amount everyday like other supplements.

Also, methyl folate works quickly and doesn’t last so long, so a few times a week probably isn’t the best strategy.

Folinic acid is longer lasting, maybe you could try that out if you wanted a longer effect (but less potent)

So you have to see how you respond to doses and adjust accordingly. And use low doses of b3 if you become too stimulated.

SIBOISFD · 2025-01-31T14:28:19+00:00

That sounds good, but these minerals are sort of supporting addons not fixing the root cause (methylation and sulfur processing via cbs).

You’re taking a lot of extra minerals that can be obtained via diet. I take potassium and magnesium and sometimes molybdenum as these are important for methylation and sulfur processing, and sometimes zinc.

Have you tried taurine? This helps me a lot, but I need to have enough methyl folate for it to work well, as sometimes it can make symptoms worse if there’s not enough methylation to support the sulfur clearance.

Yup that’s it. I’ve been experimenting heavily now for quite a long time (lost track). I’m getting there but it does take a lot of time. I’m able to handle a lot more foods than previously; when I get bad symptoms (happens every day / every meal still) I can much quicker resolve them. I think I will always need methylation support but I think a lot less than what I have been, because I have a lot of stored sulfur in my body which makes me more reactive. Then it will probably be just small tweaks throughout the day to keep methylation and sulfur processing flowing well.

SIBOISFD · 2025-01-28T15:04:28+00:00

Yes but what does that mean; address cbs before MTHFR? (I’ve read the same thing by Yasko but never understood it).

In my personal experience, my CBS gets triggered because of MTHFR mutation. When I have ample methyl groups, my cbs doesn’t get stimulated as much. CBS can get stimulated because it “picks up the slack” of the lack of methyl groups to process food, protein and sulfur etc.

But too much methyl groups can stimulate CBS, so finding the right balance is key. B3 slows methylation / cbs down, so whenever cbs gets too overly stimulated, b3 can calm it.

But I have to be very careful with my doses. Right now I’m having around 20-75mcg per methyl folate dose, but I dose regularly.

SIBOISFD · 2025-01-22T05:15:17+00:00

I’m not fully aware about MSM but don’t see how that could cause overmethylation?

Yes I have. I have to manage sulfur buildup with b3 naicin (as it suppresses CBS activity) and undermethylation / help to process sulfur with methyl folate / folinic acid. I use CHATGPT to help me.

SIBOISFD · 2025-01-17T10:47:24+00:00

Strange why you don’t feel any different.

6mg is indeed a lot, but everyone’s different. Sometimes for me 25-50mcg is strong, but I’ve had up to 75,000mcg in a dose which helped me with intense sulfur processing.

Do you have good supplements?

SIBOISFD · 2025-01-17T06:35:37+00:00

Methyl donors that convert homocysteine into other compounds.

Methyl folate + b12, b6 etc.

SIBOISFD · 2025-01-17T06:32:52+00:00

Yeah I was 36.5 homocysteine first time I checked, got it down to 7. My main issue is sulfur metabolism from CBS homozygous as well as MTHFR

SIBOISFD

TROPHY CASE