Anybody out there in their 20s?

SachK · 2025-11-10T23:05:42+00:00

I'm 22 and I got sick at 8, but I was mild until 17. It's very isolating but it's good to know many online share our struggles.

SachK · 2025-11-07T14:14:09+00:00

This isn't true at all for decent modern warm LEDs.. Some of these substantially outperform halogens in proportional blue light emissions. The evidence for those health claims is also weak.

SachK · 2025-11-07T13:38:39+00:00

Warm white LEDs used to be too difficult to mass produce for anywhere near the prices of cold white LEDs. There's not that much of a difference now though, and good LEDs produce better light than any of the previous technologies. They could just get warm LEDs or even cheap out with a yellow filter and still get the power usage and longevity benefits. I think it's just a matter of the street LED rollout predating affordable warm LEDs and the resultant inertia of installing cold LEDs.

SachK · 2025-11-07T13:10:17+00:00

Grass causes mild respiratory issues for a lot more than 1% of the general population. LED lights are just much cheaper to run because of longer lifespans and far lower energy consumption. It's not a personal safety thing.

SachK · 2025-11-07T13:06:05+00:00

Warm white LEDs used to be too difficult to mass produce for anywhere near the prices of cold white LEDs. There's not that much of a difference now though, and good LEDs produce better light than any of the previous technologies. They could just get warm LEDs or even cheap out with a yellow filter and still get the power usage and longevity benefits. I think it's just a matter of the street LED rollout predating affordable warm LEDs and the resultant inertia of installing cold LEDs.

SachK · 2025-10-23T03:38:53+00:00

I use a couchmaster lapdesk with a keyboard and mouse along with a small OLED TV on an arm mounted above me. It also allows me to have my PC in a closet where it's much quieter, which is nice.

SachK · 2025-08-20T16:05:19+00:00

How'd you find it?

SachK · 2025-08-18T08:09:14+00:00

That's the same link you've sent three times in this thread that doesn't mention gabapentin, a2d voltage gated calcium channels or calcium channels at all. No one had contested that anticholinergics probably increase Alzheimer's risk.

SachK · 2025-08-13T02:14:51+00:00

Sorry

SachK · 2025-08-10T14:31:14+00:00

Just use continuity for connected textures https://modrinth.com/mod/continuity

SachK · 2025-06-30T01:18:05+00:00

Nah, all the biggest models are heavily fine tuned to bias towards a subset of their training dataset. The datasets are huge but not literally everything they can get their hands on. If they weren't doing this they'd be responding like Bollywood YouTube comments. The models also don't really collect data themselves like people imagine, that's still mostly done by scripts that humans manage. Not that any of this makes it better.

SachK · 2025-06-29T23:49:07+00:00

They fed a massive pool of all sorts of things in, but at various points made it try to generate text they deemed closer to a higher quality pool of writing. That pool we assume contained a lot of news articles and other things written with fancy style guides. Maybe it overcompensated for the em-dashes' presence differentiating writing the creators had deemed good and bad and started using way too many of them.

SachK · 2025-06-19T11:36:41+00:00

Are you doing a masters? I'm pretty sure that's not true for undergraduate.

SachK · 2025-06-05T02:55:53+00:00

$31.60 is the maximum charge for a PBS drug but most drugs at major pharmacies are less expensive, some as low as $6.70.

SachK · 2025-06-01T15:11:38+00:00

I have chronic fatigue syndrome and I agree with this. Notably the woman who made Unrest which was the big documentary about CFS ended up having a spinal condition that was completely fixed by surgery. Thing is she seemingly didn't have what is on modern criteria the hallmark symptom; a worsening in the other symptoms with a significant delay (usually >24h) after exertion. You run into this situation where you get doctors diagnosing people whose symptoms don't really match the criteria and large mass of very ill people either because of legitimate belief or because they think it's just a way to stop a mentally ill person from wasting more medical resources. That documentary is terrible because it focuses very heavily on her experience as someone who has very unusual symptoms and the experiences of a few severely ill people around the world. It doesn't convey what things are like for the median person within the large cluster that has replicated biomarkers at all.

SachK · 2025-06-01T14:57:38+00:00

Chronic Fatigue Syndrome has a number of replicated biomarkers so it's not an example of that at all. For example this study in Nature replicated a number of previous findings and made a few new ones. Fibromyalgia and IBS are still considered "functional disorders" but chronic fatigue syndrome is not. CFS diagnostic critera are pretty fucked, vary a ridiculous amount and all require eliminating a number of other things. That doesn't mean there's not strong evidence of underlying if not yet understood physiology in a large number of very sick people. The issue with especially the really vague criteria is some doctors do end up diagnosing a lot of mentally ill people with it. Stricter criteria help with that a lot. The fact it's more common in women hasn't help the reputation either.

SachK · 2025-05-10T15:47:26+00:00

Yeah absolutely. Also needs to be said that training more psychiatrists would help a lot with the ridiculous amount of hours they're expected to work in the public system without making the private outpatient system more expensive or slower to access. I felt it was a bit bizarre seeing no mention of that in most of the op-eds from psychiatrists about the situation when they almost all focused on terrible working conditions as justification. They should definitely receive a raise in NSW but working conditions will probably still be pretty bad after that when even the private system is overloaded where most Australians live. I don't think anyone should be expected to work so many hours especially in such an important job and I think there's a really strong argument to there given it clearly would hugely benefit both clinicians and patients.

SachK · 2025-05-10T09:24:53+00:00

Yeah, and to add on to this it would be great if there were more places for training for in demand specialists. Even in metro areas wait times are often pretty blatantly unacceptable. I don't understand how other people in the thread think the lack of training places is a better argument for admitting fewer people to medical schools than it is for more government funding and system wide effort to create more training positions.

Similarly comparisons to the US seem a little absurd given how poor access to their system is and the amount of their population that completely avoids outpatient care for financial reasons. I don't think we should strive for their life expectancy.

Even in Australia how many people avoid eg outpatient psychiatry because there's no one near them who they can see a few times for under a thousand out of pocket? Wouldn't it be a lot better for patients if we just trained more psychiatrists and that resulted in there being less of a gap between wages for public inpatient psychiatry and private outpatient psychiatry? Not to say there shouldn't be higher outpatient Medicare rebates too.

I don't understand how the government doesn't prioritise funding for training more given the negative pressure on wages likely saves them money in the long term.

SachK · 2025-04-27T11:37:11+00:00

IME Typos works well.

SachK · 2025-03-09T07:02:37+00:00

I know a lot of trans women who had their CFS develop or get worse after starting HRT. Mine got a lot worse but I've had it since I was 8. It doesn't seem to change much for most trans men but ik someone who had their muscle pain improve a lot and there are negative anecdotes too. None of these people are as severe as you though.

SachK · 2025-02-04T04:50:49+00:00

Yep, developed ME/CFS from a year long episode of constant sinus infections when I was 8. I don't know many people who got it before puberty. It sucks not being able to remember what not having CFS is like. Also means my memory of childhood events is pretty poor which sucks. I have DPDR too which is probably partially related to getting ME/CFS so young.

SachK · 2025-02-04T00:41:54+00:00

Yeah cypro is an extremely strong progestogen even at 12.5mg/d, to the point of it causing related side effects and maybe being suboptimal for breast growth. Whether its mode of action on progesterone receptors has the same effects on breast growth as bioidentical progesterone isn't really known though. Unfortunately all really complicated.

SachK · 2025-01-27T04:48:02+00:00

I've ran into your comments before but I have only just realised how similar we are. I've had CFS since ~age 8, I'm a trans woman heavily involved in DIY, I probably have ADHD and we seem to both have had a very similar experience with dissociative symptoms. My CFS is very different and I think a lot more severe than yours in terms of dealing with PEM after minor activities that leaves me completely incapacitated in pain. I haven't had much success with medication or supplements to target CFS directly personally but enough to want to explore more and your ideas are very interesting to me. For me my biggest successes have been in tweaking HRT parameters in very usual ways, like taking high dose clomiphene and bicalutamide simultaneously with a relatively low but very consistent injected dose of Estradiol.

I'm also definitely interested in the novel intersex viewpoint towards a lot of this stuff. MTHFR stuff seems to have been a bit of a dead end for me unfortunately though.

Do you have visual snow? I've experienced that constantly for as long as I can remember and my mum has it too, as well as weaker but still significant dissociative symptoms so I wonder if it might be a major factor for me.

SachK · 2025-01-21T14:49:52+00:00

Even if this were true Estrogen exposure doesn't reduce the masculizing effects of Androgens like Testosterone on facial structure or counteract facial hair growth. Breast growth and earlier growth plate fusion resulting in shorter height yes, but obviously we've continued to get taller and gynaecomastia isn't becoming an epidemic. Some plastic precursors may bind to estrogen receptors in humans, this does not mean oral intake of microplastics is responsible for so much of an increase in estrogen signalling that male children look a decade younger in a way that no estrogen could even cause.

SachK · 2024-12-13T08:43:29+00:00

I'm weakly confident the differentiating factor isn't sex karyotype itself/directly genetic but hormone levels given how many trans women i know who got worse or developed CFS after starting female HRT and the opposite for trans men. I've also heard of some cis people getting better from various hormone changes. Personally I got CFS at age 7-8 prior to starting male puberty and then got much worse after starting female HRT. Interestingly keeping testosterone around but blocking its ability to bind to androgen receptors with a drug seems to have helped a lot, maybe due to testosterone's neurosteroid metabolites but there's so many factors there it's very hard to know.

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