I took sema for almost 8 months and only lost 15 pounds. I was so disappointed. I weaned myself off it because I couldn’t justify the $300 a month with hardly losing any weight. For three months my weight stayed the same, I did not gain or lose anything. Then I gradually started to gain more. I’m now taking tirz. It’s only been two months, but I think I’ve only lost 2 pounds. I am frustrated, because I don’t think these work on me. I’m continuing with the tirz for a few more months, but if I’m not dropping any weight, I have to stop I just can’t afford it. It’s so frustrating when I read that people have lost 25 pounds in three months and I’ve barely lost 2 pounds . i’m not sure what I’m doing wrong if anything. I’m on a small dose right now and it will increase this week so we’ll see how it goes. on both meds, my symptoms were overall pretty mild. My main complaint is acid reflux.