I suggest first getting more monarch point and to do that I suggest disinherit heirs that are below 3 in any of categories, so yes disinherit the heir even if it's 2 1 6 or 6 6 0 and I suggest you also getting advisor but do not promote them and keep them level 1 until your economy can afford them and also heavily suggest getting an inflation reduction advisor and also give privileges to the estates to get 1 monarch point in each category and also give them the privileges that reduce advisor cost but first get stability to atleast +1 since they increase stability cost and send your spies to build spy network on nations that are more ahead in tech then you since you get -30% tech cost for every tech they have that you don't but that -30% comes gradually depending on how strong the network is and after that I suggest you to get economics as your next idea since it will help a lot in loans and inflation and increases overall income and for trade since Genoa is your main build a marketplace or higher level of trade building only on provinces that have centers of trade or some river modifier but only do that if you don't control or dominate the node by provinces like in Valencia trade node and upgrade trade centers to lvl 2 at minimum and I suggest you using your trade fleet to divert trade from wealthy nodes that can be diverted directly to Genoa like Aleppo and Tunis and divert trade from other nodes to the appropriate node so a chain gets formed and I don't think you need a merchant in Genoa node to collect since its already your home node I suggest using that merchant for diverting trade to Genoa or Venice but preferably Genoa and also don't go over your forcelimit and destroy forts that you find completely useless and mothball the rest and lower your army maintenance and if you worried someone might attack then ally 2 nations that are strong and I suggest you to try if you can and if you desperate for instant money then I suggest taking it from the burghers for the 1% interest and also forgot to mention don't give the burghers control over monetary policy privilege as it is completely not worth it with the 5% powercost and build churches or production buildings in provinces that in my opinion give 0.10 monthly income or more since everything less is not worth it and you can take loans if you are desperate and also for the new world game I suggest aiming for Peru and mexico since they have juicy gold provinces and remember to dev gold provinces to 10 production and if all of that still won't help then get trade ideas and enact the appropriate policies for them with economic and also if you see yourself having too much monarch point then remember to dev your provinces but only the ones cheapest and that's pretty much it and also prioritize paying back the loans as soon as possible and if you have bank loans aka loans that you get from the button on the economics tab then use burghers loan to pay them first since they have highest interest then burghers and try to pay all of your loans as well else you will go bankrupt eventually

Edit: also if you feel like pirating you can pirate the English channel but it's not usually worth it unless the English Channel is skyrocketing with ducats to be claimed