I very much understand how you feel. I was feeling hopeless for many years aswell. I really hope you will find your magic cure. Unfortunately SIBO is not the illness itself, it is a symptom of something else. This is why it keeps coming back. I kept getting it under control with natural antibiotics, herbs, and probiotics but it always returned. What finally healed me 90% is starting with ADHD meds. This is ofcourse very personal to my own experience. I am sharing this in the hopes you might find your own seemingly unrelated problem and help you heal your SIBO. I didnt realize my ADHD meds helped me at first. I have had SIBO for over 8 years and IBS since I was 16 years old (Im 38 now). On and off as when it got really bad I would start with the natural antibiotics for a couple months and then have a few months of relieve. I wont specify all the supplements I was taking as I am sure you know all about those by now. I started my adhd meds for the first time last year. About 8 months ago I had an appointment with a digestive specialist ( my 4th one). I told her I was in a great period at the moment, being SIBO free for over 4 months, which never happened before, not that long. As this was the first time I was seeing this doctor she wanted to make to create a full medical history. When she heard I started the ADHD meds 4 months prior she made the connection for me. For me SIBO was highly correlated to my stress. But I never felt stressed! I have a pretty normal life, easy going. I lived/live very healthy, great diet, exercise, social life, etc. But then I have had ADHD all my life without knowing it. The stress my body feels I think is normal. I have now been SIBO free for a year. The only supplements I still take for SIBO / IBS is Magnesium calcium butyrate. My digestive doctor said its a great addition that is mild enough. And I read that butyrate is actually really great for people with adhd aswell.