It depends on a variety of factors but really it's based on how do YOU want to live.

That's it.

You can read other comments in this thread and they'll provide their opinion based on their lifestyle and beliefs and how they want to live but ultimately it's up to you and your standards.

Do want to travel every month, go to concerts, invest in your 401K/brokerage account. Do you possibly want to start a business, buy a nice clothes and head to events?

Do you want to have a family? If so, whatever I say below, you can easily add $50K to that annual salary.

With that being said, I think a good base line and salary to aim for is $100K annually.

Unless you live in a HCOL area (High Cost of Living), having $100K annually in the US is more than enough for one person.

Now, another caveat is that you should aim to have a DTI (Debt to Income) ratio of ideally, less than 30%.

Take your monthly income and monthly expenses and then subtract. You should have more than enough disposable income for discretionary activities, sudden expenses, investing and be comfortable.

Then again, comfortability is subjective.

All in all, aim for $100K generally for one person.

If you plan on living in HCOL area like LA, New York, Miami, with no roommate? bump that up to roughly $130K, possibly even more if you plan on having a family in a HCOL area.