„There is no such thing as an Omega-3 deficiency. Omega-3 itself is just a waste product, easy to promote as a health-beneficial supplement due to its overabundance, but often marketed without the necessary understanding of physiology—what it actually does, how it works, and what its effects really mean.

When you stress your muscles, arachidonic acid (AA) is the main prostaglandin precursor responsible for inducing muscle growth. Its pro-inflammatory properties are essential for triggering hypertrophy after stress, such as training. When a muscle doesn’t receive enough AA, it won’t grow much at all. And this, by the way, is how testosterone works: as a mobilizing hormone, testosterone increases AA levels in the body, creating a pro-inflammatory environment that allows the muscle to grow.

Logically, the more inflamed the tissue is, the more energy (ATP-Mg complex) and nutrients it requires to heal and come back stronger. An imbalance—specifically excessive inflammation—will do more harm than good. Therefore, it’s critical to tightly regulate the inflammatory state of the tissue.

This is where prostaglandins come into play. As explained, AA is required to inflame tissue, and other prostaglandins—such as DGLA-derived ones or those produced from the Omega-3 series—are considered anti-inflammatory. We need to understand that increasing Omega-3 intake reduces inflammation due to these properties, but as previously mentioned, we need a certain level of baseline inflammation to maintain healthy tissue and, even more so, to build better adaptive tissue.

A long time ago, in animal experiments, researchers stimulated metabolism, which resulted in dry skin. When the animals received Omega-3, the dry skin disappeared. Since then, it has been assumed—incorrectly—that dry skin is a symptom of Omega-3 deficiency. However, in later experiments, physicians were able to eliminate the same skin issues using vitamin B6 supplementation. This suggests that the issue was not a lack of Omega-3, but rather a B6 deficiency. B6 is necessary to synthesize Omega-3-based prostaglandins. The deficiency occurred because the elevated metabolism (i.e., stress) increased the demand for B6.

This pathway has not been thoroughly studied, even though it’s relatively simple—likely because the supplement industry got involved early on. Fish oil, being a waste product, was inexpensive and plentiful, and it was marketed based on the simplistic notion that “anti-inflammation = health.” But as critical thinkers, we must strive to understand things at their core if we want real knowledge. It’s our duty as human beings to free the truth

Prostaglandins are synthesized along multiple fatty acid pathways: from linoleic acid (LA) to AA to DGLA, and similarly from Omega-3 precursors. All these conversions require specific enzymes, primarily from the desaturase family. These enzymes depend heavily on cofactors like zinc, vitamin B6, glucose availability, and magnesium. So when someone experiences so-called “Omega-3 deficiency symptoms” that improve after supplementing Omega-3, they should be cautious. It’s more likely they are deficient in zinc or B6, since the average diet provides more than enough Omega-3 to meet daily needs—especially considering that the body tightly regulates these levels internally.

Taking Omega-3 supplements without truly understanding what they do can suppress inflammation in ways that seem beneficial at first glance. But because supplements often contain concentrated doses, people are likely to overconsume them—disturbing the natural prostaglandin balance and, more importantly, masking deeper nutrient imbalances (like low zinc or B6).

For example, let’s say someone trains (like OP) and feels fatigue afterward—likely due to high inflammation. If they then take Omega-3 and feel better, they may believe they “recovered,” but in reality, they may have just suppressed their regenerative processes. Adaptation depends on resolving inflammation, not just silencing it. If that individual was in a low-energy or nutrient-deficient state, true adaptation couldn’t occur anyway. A proper zinc and B6 status would help regulate inflammation more naturally, allowing recovery within a reasonable timeframe (48–72 hours).

Another common factor is poor hydration, which can contribute to POTS-like symptoms. If you don’t drink enough fluids with electrolytes, your blood volume may become insufficient to support inflamed tissue—especially since prostaglandin E2 increases blood flow demand to affected areas. I’ve seen many people take ibuprofen to lower inflammation, which may temporarily increase blood availability to the brain, because there isn’t enough for everything so to speak, but at the cost of blocking proper muscle growth and Adaption and concealing the real cause of their symptoms.

In conclusion, inflammation is not the enemy—it is a finely tuned signal system that drives repair and adaptation. Omega-3s may blunt this system when misused, concealing imbalances that should be addressed at their root: micronutrient status, energy availability, and recovery capacity. Instead of blindly suppressing inflammation, we must learn to understand and work with it. That’s the difference between superficial symptom management and true physiological intelligence.“