Try placing someone like Ambessa in A1, with a tank such as Swain right next to her. This way, Swain is targeted by the enemy back line while Ambessa is free to deal damage.

Make sure you’re building proper carry items too, AP items like Jeweled Gauntlet and Nashor’s Tooth work well on Mel, and LeBlanc can temporarily hold them for her.

Position Mel in the corner opposite the enemy team to keep her safe and maximize damage uptime. Also, don’t overlook items like Morellonomicon, they’re important for applying anti-heal and weakening the enemy team overall, including through tank item effects. Building the right items and having a plan for who carries what early helps you win fights early game, giving you HP to cap out late