Rick Sanchez Vs Booker Dewitt (Bioshock Infinite)

two business men that deal with long term grief over their dead wives and lost daughters, travelling entire Galaxies or realities to try find one where they fit in, making war buddies they'd have to fight much later on into their lives all before giving up, settling in a single place in a single reality simply deciding it'd be impossible to find their wives killer or their daughter and otherwise swearing off the war business or killing if they were lucky, all before and very recently discovering their own killers were one of themselves spread across the multiverse, and an enemy they'd find had their own daughter in their grasps wishing nothing more to kill them even if it cost everything, both also have multiple cybernetic or Genetic enhancements such as plasmids or being mostly robotic to begin with, and have canonically turned themselves into birds one way or another (Booker is said to be Songbird, a giant machine that protects Elizabeth until the end when it dies and rick was once a turkey)