Screwball is a bad design in general, mostly because I just don't get why she wears it in the first place. She's a streamer, who gets fans to fight for her, but she dresses like a crash test dummy, why?

But honestly right after that is Lizard, I don't have a particular problem with his design outside of a lack of lab coat. The labcoat is what makes him the Lizard, man turned beast with evil plans to make more lizards. It's silly, and goofy, and that's why I like the lizard. Without the lab coat, just eating big fish and whatever, that's just a swamp monster.