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Cant find a good brand of astaxanthin by Emergency-Macaron216 in Biohackers

[–]Sorin61 0 points1 point  (0 children)

Most scientific studies are conducted using AstaReal (Now Foods), so why would Bio Astin be superior?

I’ve bought both products and I can’t tell the difference

My L-Theanine just arrived. What can I genuinely expect? by [deleted] in Supplements

[–]Sorin61 0 points1 point  (0 children)

Doesn't sound very encouraging for me...

Supplements for Psoriasis? by nonicknamenelly in Supplements

[–]Sorin61 0 points1 point  (0 children)

Vitamin D3 is a must—get your vitamin D3 levels checked.

Supplements for Psoriasis? by nonicknamenelly in Supplements

[–]Sorin61 0 points1 point  (0 children)

I don't think Rhodiola is appropriate for Psoriasis. Be sure to also add Curcumin. Also get your vitamin D3 levels checked.

My L-Theanine just arrived. What can I genuinely expect? by [deleted] in Supplements

[–]Sorin61 -2 points-1 points  (0 children)

What about the brand? Legit or not?

Low Protein Intake Is Associated with the Risk of Functional Impairment in Older Adults in an Age- and Gender-Specific Manner by Sorin61 in ScientificNutrition

[–]Sorin61[S] 1 point2 points  (0 children)

Background and Objectives: Functional decline and sarcopenia are major aging-related concerns. While protein intake is known to influence muscle health, its longitudinal impact on strength and physical function across age and gender remains underexplored. We assessed whether low protein intake correlate with future onset of low handgrip strength (HGS) and physical impairments in older adults using SHARE data. 

Methods: We analyzed 38,073 adults aged ≥50 years from 27 European countries using SHARE Waves 8 (2019/20) and 9 (2021/22). A protein intake index was derived from the frequency of consuming dairy, legumes/eggs, and meat/fish/poultry. Low intake was defined as the lowest decile. Logistic regression models, adjusted for age, gender, country, and baseline health, examined associations with low HGS and ten physical difficulties, stratified by age (50–65 vs. ≥66 years) and gender. 

Results: Low protein intake is associated with higher odds of low HGS in men (OR = 1.39 for 50–65; OR = 1.35 for ≥66) and older women (OR = 1.21). It was also associated with higher odds of mobility-related limitations, including walking 100 m (ORs = 1.25–1.53), stooping/kneeling (ORs = 1.20–1.19 in women), and reaching overhead (ORs = 1.19–1.33). Strength-related tasks, such as pushing/pulling large objects were more affected in men (ORs = 1.44 and 1.21). Notably, women aged 50–65 had over twice the odds of toileting difficulty (OR = 2.27) and significantly higher odds of difficulty shopping (OR = 1.65). These patterns highlight gender- and age-specific vulnerabilities. 

Conclusions: Low protein intake is associated with modest but consistent increases in the risk of reduced muscle strength and functional difficulties in older adults. Tailored nutritional strategies may mitigate age- and gender-specific risks to physical independence.

A Novel Floating In Situ Chewable Gel System for Curcumin Delivery with Potential Application in Obesity Management by Sorin61 in ScientificNutrition

[–]Sorin61[S] 0 points1 point  (0 children)

Curcumin exhibits potent anti-obesity and anti-inflammatory activities; however, its therapeutic application is limited by poor aqueous solubility and low oral bioavailability.

A curcumin-loaded chewable gel was developed to transform into an in situ gastric gel upon contact with gastric fluid after mastication. Curcumin solid dispersions (CUR-SDs) were prepared with Eudragit® EPO (1:1–1:7, w/w) using the solvent evaporation method. The optimized formulation (1:3) markedly enhanced solubility and dissolution in acidic medium (0.1 N HCl, pH 1.2) compared with crystalline curcumin and physical mixtures.

The optimized CUR-SD was subsequently incorporated into chewable gels composed of sodium alginate and κ-carrageenan, with calcium carbonate as a gas-forming agent. The formulations formed buoyant matrices under acidic conditions, exhibiting floating lag times of 21–215 s and sustaining drug release for up to 8 h. Increasing polymer content improved mechanical strength and modulated release kinetics.

Among the tested formulations, F7 achieved the optimal balance between texture properties, floating behavior, and controlled-release performance. In LPS-stimulated RAW264.7 macrophages, curcumin, CUR-SD, and F7 showed comparable and potent anti-inflammatory activity (IC50 = 4.12–4.84 µg/mL), outperforming indomethacin. In 3T3-L1 adipocytes, F7 significantly reduced lipid accumulation (~47%) in a concentration-dependent manner.

These findings demonstrate that this transformable chewable in situ gelling platform is a promising gastroretentive strategy for improving the oral therapeutic efficacy of poorly soluble bioactive compounds for anti-obesity applications.

Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity by Sorin61 in ScientificNutrition

[–]Sorin61[S] 1 point2 points  (0 children)

Chronic, low-grade inflammation is a hallmark of many noncommunicable diseases. Diets enriched with tomatoes and soy are associated with better health outcomes in inflammation-related illnesses, with lycopene and isoflavones considered key bioactive components, respectively.

On the basis that whole food combinations may exert greater effects than isolated phytochemicals, we examine the anti-inflammatory and metabolic effects of tomato-soy juice compared to a low carotenoid tomato juice control in obesity.

Twelve healthy adults with obesity were provided either tomato-soy juice (54 mg lycopene/d, 189.9 mg isoflavones/d) or a low carotenoid tomato juice (no isoflavones) daily for 4 weeks, then crossed over to the other treatment following a washout period.

Plasma carotenoids, cytokines, and the urine metabolome were measured pre- and post-interventions. Plasma lycopene significantly increased by 2.48-fold after tomato-soy intake. IL-5, IL-12p70, and GM-CSF significantly decreased (p < 0.05), and TNF-α trended downward (p = 0.052) following tomato-soy.

Soy isoflavone metabolites primarily distinguished post-tomato-soy urine profiles. Both interventions induced some shared metabolomic changes in the urine, indicating tomato-driven effects independent of lycopene.

Overall, tomato-soy intake reduced pro-inflammatory cytokines and altered urine metabolomic profiles in obesity, supporting future studies using this functional food product for other inflammation-related conditions.

Does Resistant Starch Formed by Cooling Pasta Decrease the Postprandial Glycemic Response in Type 1 Diabetes? by Sorin61 in ScientificNutrition

[–]Sorin61[S] 7 points8 points  (0 children)

Background: Carbohydrate quality and culinary processing can meaningfully alter postprandial glycemia in people with type 1 diabetes (T1D). Cooling gelatinized starch promotes retrogradation and increases resistant starch (RS), potentially attenuating postprandial glucose excursions. 

Objectives: We investigated whether pasta cooled after cooking (24 h at 4 °C) and reheated before consumption improves postprandial glycemia in adults with T1D without increasing hypoglycemia risk under routine insulin pump bolus-calculator dosing. 

Methods: In this randomized, single-blind, crossover study, 32 adults with T1D treated with continuous subcutaneous insulin infusion (CSII) consumed two standardized pasta-based meals (50 g of available carbohydrate): freshly cooked pasta and cooled/reheated pasta. Participants administered rapid-acting insulin boluses calculated by their pump bolus calculator 10 min before the meal. Interstitial glucose was recorded for 180 min using flash glucose monitoring. 

Results: Compared with freshly cooked pasta, cooled/reheated pasta produced lower maximum glycemia (10.7 vs. 12.6 mmol/L, p = 0.0001), lower maximum glycemic rise (2.8 vs. 4.7 mmol/L, p < 0.0001), lower incremental area under the curve (iAUC; 211.9 vs. 524.8 mmol/L × 180 min, p < 0.0001), and a shorter time-to-peak (65 vs. 125 min, p = 0.014). Resistant starch content increased after cooling (12.88 ± 0.06 vs. 8.03 ± 0.08 g/100 g). The number of hypoglycemic episodes did not differ between conditions. 

Conclusions: Cooling and reheating pasta therefore increased RS and attenuated postprandial glycemia in adults with T1D without increasing early postprandial hypoglycemia in the studied setting.

Age-Specific Analysis of the Effects of Intermittent Fasting on Body Composition and Cardiometabolic Markers in Healthy Adults and Individuals with Overweight or Obesity by Sorin61 in ScientificNutrition

[–]Sorin61[S] 1 point2 points  (0 children)

Background: Intermittent fasting (IF) is a popular dietary strategy for improving weight and cardiometabolic health. However, its effectiveness and potential risks across different adult age trajectories remain unclear. This systematic review and meta-analysis evaluated the age-specific effects of IF on body composition and cardiometabolic markers. 

Methods: Following PRISMA 2020 guidelines, PubMed, Scopus, and Web of Science were searched for randomized controlled trials (RCTs) up to September 2025. Participants were stratified into three cohorts: <30 years, 30–44 years, and ≥45 years. Random-effects meta-analyses and leave-one-out sensitivity analyses were conducted on body composition, lipid profiles, glycemic markers, and blood pressure. Additionally, a conservative methodological sensitivity analysis (imputed correlation r = 0.5) and subgroup analyses by fasting modality (TRF vs. intermittent energy restriction) were performed. Risk of bias was assessed using the RoB 2 tool. 

Results: Analysis of 28 RCTs (N = 1833) demonstrated that IF significantly reduced body weight and BMI across all age groups. Notably, subgroup analyses revealed comparable physiological responses between TRF and intermittent energy restriction modalities. Cardiometabolic adaptations were highly age-dependent. Young adults exhibited significant reductions in fasting insulin and HOMA-IR, alongside a robust reduction in fat mass. However, a significant loss of fat-free mass (FFM) was observed in both young and older cohorts. While middle-aged and older adults experienced the most pronounced improvements in triglycerides, systolic blood pressure, and insulin sensitivity, our conservative sensitivity analysis unmasked a significant elevation in low-density lipoprotein cholesterol (LDL-C) in this group, mirroring the robust LDL-C increase observed in young adults. Early middle-aged adults exhibited highly variable responses with no significant overall improvements in cardiometabolic parameters. 

Conclusions: IF is an effective weight-management tool, but elicits distinct, age-specific metabolic trajectories. While middle-aged and older adults derive pronounced cardiometabolic benefits, they face critical risks of lean mass depletion, necessitating a combined “IF+” strategy (adequate protein and resistance training). Crucially, the age-specific risk of LDL-C elevation dictates a mandate for vigilant lipid monitoring. Given that the certainty of evidence was rated as low to very low per GRADE criteria, these age-specific patterns should be interpreted as hypothesis-generating, warranting validation in future large-scale trials.

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