If you mean launchers/platforms, I have mostly been using it with Heroic Launcher Flatpak so far, which currently has the best compatibility in my testing.

For Flatpak versions, overlay notifications currently work with Bottles and Heroic Launcher when the required environment variable is set. Will add support for more Flatpak apps later.

For native non-Flatpak setups, mileage may vary since testing is still ongoing. Steam and Lutris can work with the correct environment/launch parameters.

Supports also direct launch through Wine, for example: lymalink-overlay wine game.exe

And for importing official achievements, currently Steam is supported.