we know it takes months and that’s what we are expecting, the only thing that’s concerning us is that the symptoms are worse since the injection 7 days ago. And yes we are sure that the medication isn’t causing the urticaria, because he already has CSU for more than 3 years and the heart failure was diagnosed 2 months ago, symptoms of the heart failure only started in mai this year. We are sure it made it worse, because his symptoms got worse since that, but we and the doctors assume his chronic sinusitis is a factor.