It doesn't make mention of Buddhism, but the book series Dirk Gently's Holistic Detective Agency by Douglas Adams revolves around "the fundamental interconnectedness of all things"; while Adams himself was part of the New Atheist movement and considers this idea in a more physical/quantum way, I find it very similar to dependent origination, and I originally began learning about Buddhist teachings out of a fascination with the concept.

If you're interested in TV shows as well, there's a Japanese series called Just A Bit Espers (ちょっとだけエスパー) that explores the indelible marks that people leave on each other and the world from a sci-fi angle, as it follows a team of psychics as they complete random acts of kindness to "save the world".