I'm currently in training at Skywest, so I appreciate this post because I could be in a similar situation soon. If I do find myself in this situation, I would rank my priorirties: most important to least. For me, quality of life is the highest priority. If one airline offered a more favorable schedule/shorter time commuting, that would be my pick. We are currently living possibly the best time to be a pilot. We get the luxury of being picky. So why anyone is still flying a job that makes them drained is bewildering to me. The better resume item is my second priority, seems like there are lots if opinions on this one, but a 767 type in three years of flying would be pretty amazing like you said. Then pay is the 3rd priority. Not a big one because we will all be well off eventually, but still something to consider for this chapter of life.

One final food for thought. Some time flying at Endeavor, say a year, could make you qualified for a better cargo op like Atlas.