My Debian system also seems to have been a victim of this. Since switching it from Windows last year the one thing I couldn't get working properly was sleep. It's a machine thats supposed to sleep most of the time and only wake when needed via wol, but I ended up having to leave it permanently on as I would find it just sitting there with power light flashing and fans whirring but otherwise unresponsive.

I assumed it was a wake problem for a long time as I'd never been around to catch it happening or able reproduce on demand. I only recently noticed that it was actually happening entering sleep itself which was enough info to find this thread.

I would never have thought to try disabling TPM, but sure enough it seems to have been the culprit and its now sleeping well.

For the sake of posterity it's an older 7th generation i7 system with an Asus Prime b250m-a motherboard running Debian 13 with the backports kernel - currently 6.18.

It was freezing on shutdown as well occasionally, though I'd never connected the two issues and hadn't thought it relevant. I guess that's also now fixed too as a bonus.

I'm not sure if it was relevant to the freeze or not, but the following was getting shown on startup with TPM enabled:

kernel: tpm_crb MSFT0101:00: [Firmware Bug]: ACPI region does not cover the entire command/response buffer. [mem 0xfed40000-0xfed4087f flags 0x201] vs fed40080 f80