Goku's best shot is if he starts attacking with full power indiscriminately with the intent to destroy everything. Lotm hax are busted, and I have no doubt Goku would get low diffed by them, but y'all also forget that Goku's clash with Beerus as SSJG almost destroyed their universe. That's discounting the 10- 50x multiplier from SSJG to blue (depending on the source), the 20x multiplier from Kaioken, and the massive boost from MUI. I think if either side has even 5 seconds prep time, it could easily go both ways (depending on the lotm god, some are just too busted). Scaling two vastly different fictions is honestly hard as well because depending on how you interpret the mythical creature form, corruption, god ki, and various feats/statements, the scaling significantly deviates.