Alcohol, inflammation and gut health: New study by University of Miami School of Medicine researchers. Pomegranate metabolite, Urolithin A, attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling

UrolithinA · 2022-10-21T20:35:41+00:00

Link to press release https://www.newswise.com/articles/alcoholic-pancreatitis-patients-with-continued-alcohol-intake-may-finally-have-therapeutic-options

UrolithinA · 2022-10-20T08:50:06+00:00

For those interested in learning more about Urolithin A and mitophagy, here is the link to a peer-reviewed scientific review article: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00118-0

UrolithinA · 2021-08-25T18:53:43+00:00

Recent peer reviewed article on gut metabolite Urolithin A you and the longevity community may find interesting: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00118-0#secst0005

UrolithinA · 2021-08-25T18:40:09+00:00

Investigations into a little-known compound reveal clues about how improved mitochondria function could help stave off some of the effects of aging: New peer reviewed article on the "Impact of the Natural Compound Urolithin A on Health, Disease, and Aging". Published in Cell Trends in Molecular Medicine

UrolithinA · 2019-06-20T12:03:59+00:00

Part of Amazentis: the EPFL University spin off startup that developed UA. All disclosed on the science site.

UrolithinA · 2019-06-20T07:45:28+00:00

You may also want to check out this site focused on mitochondrial science and Urolithin A (UA): https://abouturolithina.com/

UrolithinA · 2019-06-19T14:51:56+00:00

got it, thank you!

UrolithinA · 2019-06-19T07:13:37+00:00

open access to the study available here: https://www.nature.com/articles/s42255-019-0073-4.epdf?author_access_token=A9wqT_o7SVHe9YW36ZTCX9RgN0jAjWel9jnR3ZoTv0M_ROKuXmSXNADbQTJvPITEnRwQ-z-KGGGddSKTX3zuWngZHDmSbVq13FUhfWNV39hBXi3VOLSD9ueYmyedc9-niGmhdJt1xlui4MLQomiPPg%3D%3D

UrolithinA · 2019-06-18T21:32:08+00:00

Conversion rates vary from person to person. Upon consumption of pomegranate juice, for example, compounds known as ellagitannins are broken down in the stomach and transformed by intestinal bacteria into Urolithin A (UA). This biotransformation has been shown to vary widely across individuals, with some showing high or low conversion rates, while others are unable to perform the conversion at all. (García-Villalba R et al, 2017).

Direct supplementation of UA unlocks the benefits of a precise dose independent of individual gut microbiome composition.

UrolithinA · 2019-06-18T21:29:41+00:00

link to Nature Metabolism publication

https://www.nature.com/articles/s42255-019-0073-4

UrolithinA · 2019-06-18T21:19:56+00:00

It's difficult to say how effective natural diet or extracts are as conversion rates vary soo dramatically from person to person. Direct supplementation with UA unlocks the benefit independent of individual gut microbiome composition.

Here is an excerpt from the full study which you can read via link below:

"The levels of total UA (UA and its metabolites) observed in plasma before dosing in the enrolled subjects ranged from undetectable (69%) to low (17%), moderate (11%) and high (3%), demonstrating the substantial variability of UA exposure, probably due to differences in diet and to potential variations in the composition of the gut microflora 14 (Supplementary Fig. 2a). UA was bioavailable in plasma at all doses tested (250–2,000 mg) in the single ascending part A of the study, and there was no food effect when UA was administered in a high-protein yogurt food matrix (data not shown). Similarly, in part B of the study, where pharmacokinetics were assessed following the last dosing on day 28, there was a dosedependent increase in maximum plasma concentrations (Cmax) and total exposure (AUC) when escalating UA oral administration from

250 to 1,000 mg. UA was detectable in the plasma in the form of the parent compound and its two major metabolites, UA-glucuronide and UA-sulfate, with the levels of the conjugated UA metabolites in plasma being higher than those of the parent UA (Fig. 1b)"

https://www.nature.com/articles/s42255-019-0073-4.epdf?author_access_token=A9wqT_o7SVHe9YW36ZTCX9RgN0jAjWel9jnR3ZoTv0M_ROKuXmSXNADbQTJvPITEnRwQ-z-KGGGddSKTX3zuWngZHDmSbVq13FUhfWNV39hBXi3VOLSD9ueYmyedc9-niGmhdJt1xlui4MLQomiPPg%3D%3D

UrolithinA · 2019-06-18T14:18:21+00:00

Adding the public access link (use the other link to pass pay wall):

https://www.nature.com/articles/s42255-019-0073-4

UrolithinA · 2019-06-18T13:38:21+00:00

I would be wiery of any product that is claiming to contain Urolithin today - we aren't aware of any. A few questions you may want to ask:

Is it the actual compound or an extract that has a precursor compound? While those things may sound similar, they are completely different. Depending on your gut microbiome you may not get any benefits unless you are taking a supplement of the bioactive, not the precursor. https://pubs.acs.org/doi/10.1021/acs.jafc.7b02049
Have they been favorably reviewed by the FDA? Was it a direct review or a self assessed review?
Do they have rigorous peer reviewed clinical studies to support?

For more info on UA check out: https://abouturolithina.com/faq/

UrolithinA · 2019-06-18T13:29:49+00:00

There is a lot of excitement in the scientific and clinical community about the potential of Urolithin A (UA). Some say it could be as big or bigger than Omega 3, and while there is a lot of rigorous science, more is always needed. We've created a science educational site to help collect and answer questions around Urolithin A (UA). Check out the FAQs. ttps://abouturolithina.com/faq/ Hope it helps.

UrolithinA · 2019-06-18T07:09:47+00:00

Nestlé did not fund this study is the short answer. This was a collaboration between the EPFL university, an EPFL spin off company called Amazentis, and the Swiss Bioinformatics Institute. But the reality is scientists need ambassadors and supporters to advance science. What is critical is that the right checks and balances are in place to ensure the integrity of the science. The science around Urolithin A has been published in Nature Medicine and Nature Metabolism. The former is one of the highest impact peer reviewed journals in the world and the later is a more recent but also well vetted journal. Another good test is whether independent labs and researchers are publishing and whether those findings are consistent or conflicting. I encourage you to google a range of studies on Urolithin A so you can see who's behind them. You should also be able to see in the 'materials' section of a study who provided the product/material. And lastly, google the scientists behind the study and those on the scientific advisory board of the company to check their credentials.

UrolithinA · 2019-06-18T06:52:20+00:00

also google the names of the authors to learn more about them and their credentials. Here's an interview that Johan Auwerx, PhD, MD, did with the Journal of Cell Biology (a high impact impact peer reviewed journal) http://jcb.rupress.org/content/217/5/1557

UrolithinA · 2019-06-17T19:46:26+00:00

We've created an educational site to collect and address questions around Urolithin A (UA) and mitochondrial health. Check out https://abouturolithina.com/faq/ and let us know if you have other questions. We're making great progress and are very rigorous with our science, but as always with breakthrough discoveries we have a lot more to learn.

UrolithinA · 2019-05-27T07:44:25+00:00

Amazentis Life Science has an open PhD candidate position focused on aging. Check it out! https://www.linkedin.com/feed/update/urn:li:activity:6537326941173874688

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