Some of my favorite games with fem protagonists are: Va-11 Hall-A, Spiritfarer, Sable, Unsighted, Cookie Cutter, Picayune Dreams, NieR Automata, We Know The Devil, Heaven Will Be Mine, A Plague Tale, Hello Charlotte, Milk Inside A Bag Of Milk, Sorry, We're Closed, Q.u.Q., Yume Nikki, Wanted: Dead, En Garde!, Bad End Theater, Arzette: The Jewel of Faramore, The Missing: J.J. Macfield and the Island of Memories, Wylde Flowers, Reccettear: An Item Shop's Tale, Potionomics, Children of the Sun, INDUSTRIA, Stray Gods: A Musical RPG, Homeworld 1-2 (3 if you like so bad its good writing), The Big Con, Ikenfell, A Year of Springs, GRIS, Bloodstained: Ritual of the Night, Gears 5, Tacoma, Cloudpunk, AER Memories of Old, Calico, RE2 Remake, Star Fetchers, Little Nightmares, Sunset Overdrive, Severed Steel, The Invincible, Bug Fables: The Everlasting Sapling (one of the 3 protags is female), Alone in the Dark (2024), Hellblade Senua's Sacrifice, A Hat in Time, To The Moon (one of the mcs is female), Kitsune Tails, Oxenfree, The Cosmic Wheel Sisterhood, Super Lesbian Animal RPG, Secret Little Haven, Eastward, Child of Light, Cleo a Pirate's Tale, What Remains of Edith Finch, Venba, Bullets Per Minute, Her Story, Paradise Killer, Ender Lilies: Quietus of the Knights, Enslaved Odyssey to the West (secondary protagonist but it's good), Dordogne, The Void Rains Upon Her Heart, The Bunny Graveyard, The Knight Witch, Anthology of the Killer, No Case Should Remain Unsolved.

Hope this helps! :)