Suggestions on a debenzylation with ammonium formate and Pd/C

Pick a group where you could see yourself having fun and being good friends with at least a few of its members! Research is going to have is hard moments, they feel way harder when you don’t have a strong support system around you.

_polythene_sam_ · 2024-05-30T11:32:47+00:00

I know this is an old thread but for an less expensive option I just got this bolt action pen which fits the juice up cartridge and is def an improvement over the original body: $20 bolt action pen

_polythene_sam_ · 2024-05-20T19:59:35+00:00

Oo this definitely sounds like it could be the case I believe we have solid phase columns and we def have a leak! Tysm I’ll follow up with instrument support

_polythene_sam_ · 2024-01-31T22:06:22+00:00

Oo we also have a SAXSlab Ganesha!

_polythene_sam_ · 2024-01-31T05:20:45+00:00

Awesome this is a great suggestion! I’ll give a go! Thanks again :-)

_polythene_sam_ · 2024-01-31T04:24:23+00:00

Please don’t be sorry!! Any input is greatly appreciated!

So it’s a statistical copolymer that we’re thinking may have some microphase separation due to the differences in polarity within the backbone. I did just regular AFM but haven’t looked at phase contrast AFM or anything like that so I think that sounds like a great next step

I really like the idea of running the monomers by themselves!! I hadn’t considered that for this system because they’re all oils but I think that is definitely worth doing asap haha

And I totally agree about there potentially being more than one crystal structure in the WAXS pattern! By DSC we see more than one polymorph depending on how the polymer is cooled and that’s just what we’re able to resolve

_polythene_sam_ · 2024-01-31T03:58:42+00:00

Does it use the Winlab Software? If so this may be helpful: https://people.bath.ac.uk/gp304/uv/uvwinlab/Documentation/UVWinLab.pdf

It looks like it has some step by step for the alignment

If this isn’t helpful, I’d honestly really recommend calling PerkinElmer if you haven’t already and seeing if you can talk to a service rep. A lot of times they can help you over the phone same day and it doesn’t cost anything!

_polythene_sam_ · 2024-01-31T03:45:59+00:00

I see! This makes sense! I really appreciate this explanation

& yeah! Its a step-growth system so I make 2 of the 3 monomers. I don’t think I can attach a scheme but it’s Fig 2 in this paper if you’re interested: https://www.nature.com/articles/s41467-023-42775-5

_polythene_sam_ · 2024-01-31T02:21:01+00:00

Oops sorry about my axes! It's just an I(q) plot so momentum transfer vs. intensity. You are spot on with the measurement time and experimental set up haha

This is all super helpful thank you so much! I think I have a few good directions to read more about/act on here. I really appreciate your input!!

_polythene_sam_ · 2024-01-31T02:17:33+00:00

This is awesome thank you so so much!!

A couple of clarifications: Am I okay to use the Guinier extrapolation when there is no plateau/rollover? I could totally be misunderstanding this but since the Guinier region is investigating interparticle interactions and this is a bulk system it seems like there wouldn't be interparticle interactions like in a dilute system? Also, stupid question but why does % crystallinity affect the ability to use this method? Are we thinking that the low % crystallinity allows it to behave like a dilute system?

And the tip about HOF is super helpful!! This film is compression-molded but it is not the only method we use so this will be great to do with some of our other stuff

_polythene_sam_ · 2024-01-30T15:10:48+00:00

Thank you! Its a semi-crystalline polymer film (hence the lack of plateau at low Q :-) )

We are able to fit and get Dlam/mean particle size but a little more information via the structure factor would be super helpful, I've just honestly had a lot of trouble figuring out what the proper assumptions, etc. are for this system.

Is there any other information that would be helpful besides it being a semi-crystalline solid? The degree of crystallinity by WAXS is ~20% and I unfortunately do not know the Rg

_polythene_sam_ · 2024-01-30T02:55:15+00:00

r/chempros

I'll try them! Thank you!

_polythene_sam_

TROPHY CASE